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    CSN6A COP9 signalosome subunit 6A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835727, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSN6A
    Official Full Name
    COP9 signalosome subunit 6A
    Primary source
    TAIR:AT5G56280
    Locus tag
    AT5G56280
    See related
    Araport:AT5G56280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    COP9 signalosome subunit 6A; MXK23.2; MXK23_2
    Summary
    one of two genes encoding subunit 6 of COP9 signalosome complex. Protein contains a MPR1p and PAD1p N-terminal (MPN) domain at the N-terminal region and belongs to the Mov34 superfamily. Mutant and antisense expression result in a number of developmental defects and in ubiquitin/proteasome-mediated protein degradation.
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    Genomic context

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    See CSN6A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (22783384..22785605, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hapless 8 Neighboring gene ncRNA Neighboring gene Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase Neighboring gene WRKY DNA-binding protein 2 Neighboring gene peroxin 5 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 protein forms an SCF ubiquitin ligase and regulates hypocotyl elongation. Franciosini A, et al. Mol Plant, 2013 Sep. PMID 23475998
    2. An alternative tandem affinity purification strategy applied to Arabidopsis protein complex isolation. Rubio V, et al. Plant J, 2005 Mar. PMID 15703063
    3. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Peng Z, et al. Plant Cell, 2001 Nov. PMID 11701877, Free PMC Article
    4. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Schwechheimer C, et al. Science, 2001 May 18. PMID 11337587
    5. The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses. Feng S, et al. Plant Cell, 2003 May. PMID 12724535, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
      Title: Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125011.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COP9 signalosome subunit 6A
    NP_568839.1
    • COP9 signalosome subunit 6A (CSN6A); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); BEST Arabidopsis thaliana protein match is: COP9 signalosome subunit 6B (TAIR:AT4G26430.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22783384..22785605 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125011.4 → NP_568839.1  COP9 signalosome subunit 6A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84WB5, Q8W206, Q941I1, Q9FG76
      UniProtKB/TrEMBL
      A0A178UD14, A0A384LEP1, Q1EC57
      Conserved Domains (1) summary
      cd08063
      Location:9 → 313
      MPN_CSN6; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in COP9 signalosome complex subunit 6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W206.2

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