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    DWA3 Transducin/WD40 repeat-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842414, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DWA3
    Official Full Name
    Transducin/WD40 repeat-like superfamily protein
    Primary source
    TAIR:AT1G61210
    Locus tag
    AT1G61210
    See related
    Araport:AT1G61210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DWD hypersensitive to ABA 3; F11P17.7; F11P17_7
    Summary
    DWA3 encodes a DWD(DDB1 binding WD40) protein. Invitro analyses suggest its involvement in the negative regulation of ABA responses.
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    Genomic context

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    See DWA3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (22564359..22572029)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene LRR and NB-ARC domains-containing disease resistance protein Neighboring gene homeobox-leucine zipper protein-like protein Neighboring gene bromodomain 4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DWA3, an Arabidopsis DWD protein, acts as a negative regulator in ABA signal transduction. Lee JH, et al. Plant Sci, 2011 Feb. PMID 21421380
    2. The Arabidopsis lue1 mutant defines a katanin p60 ortholog involved in hormonal control of microtubule orientation during cell growth. Bouquin T, et al. J Cell Sci, 2003 Mar 1. PMID 12571277
    3. KTN80 confers precision to microtubule severing by specific targeting of katanin complexes in plant cells. Wang C, et al. EMBO J, 2017 Dec 1. PMID 28978669, Free PMC Article
    4. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    5. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104802.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortical microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule severing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule severing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of katanin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of katanin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Transducin/WD40 repeat-like superfamily protein
    NP_001185277.1
    • Transducin/WD40 repeat-like superfamily protein; FUNCTIONS IN: nucleotide binding; LOCATED IN: CUL4 RING ubiquitin ligase complex, heterotrimeric G-protein complex; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, LP.08 eight leaves visible, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1).
    NP_176316.4
    • Transducin/WD40 repeat-like superfamily protein; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G11160.1); Has 121273 Blast hits to 45862 proteins in 1282 species: Archae - 102; Bacteria - 12578; Metazoa - 49683; Fungi - 26785; Plants - 15760; Viruses - 206; Other Eukaryotes - 16159 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22564359..22572029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198348.2 → NP_001185277.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WSQ3
      Conserved Domains (4) summary
      COG2319
      Location:7 → 253
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam13925
      Location:1022 → 1173
      Katanin_con80; con80 domain of Katanin
      sd00039
      Location:19 → 56
      7WD40; WD40 repeat [structural motif]

    2. NM_001333941.1 → NP_001322807.1  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EJW7

    3. NM_104802.5 → NP_176316.4  Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176316.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8AV57, F4HTH8, F4HTH9, O22725
      UniProtKB/TrEMBL
      A0A5S9WSQ3
      Conserved Domains (4) summary
      cd00200
      Location:8 → 260
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:670 → 908
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:19 → 56
      7WD40; WD40 repeat [structural motif]
      pfam13925
      Location:1024 → 1175
      Katanin_con80; con80 domain of Katanin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4HTH8.1

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