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    AOX2 alternative oxidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836542, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AOX2
    Official Full Name
    alternative oxidase 2
    Primary source
    TAIR:AT5G64210
    Locus tag
    AT5G64210
    See related
    Araport:AT5G64210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ALTERNATIVE OXIDASE; alternative oxidase 2; MSJ1.5; MSJ1_5
    Summary
    encodes an isoform of alternative oxidase, which is expressed in rosettes, stems, and roots. Transcript accumulates in dry seeds and decreased upon germination and is not affected by actinomycin A. Protein is localized to mitochondria.
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    Genomic context

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    See AOX2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (25683770..25685731, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene tropomyosin Neighboring gene neuronal PAS domain protein Neighboring gene serine/arginine-rich splicing factor-like protein, putative Neighboring gene Calmodulin-binding transcription activator protein with CG-1 and Ankyrin domain Neighboring gene 1,8-cineole synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene for alternative oxidase-2 (AOX2) from Arabidopsis thaliana consists of five exons unlike other AOX genes and is transcribed at an early stage during germination. Saish D, et al. Genes Genet Syst, 2001 Apr. PMID 11434463
    2. Alternative oxidases (AOX1a and AOX2) can functionally substitute for plastid terminal oxidase in Arabidopsis chloroplasts. Fu A, et al. Plant Cell, 2012 Apr. PMID 22534126, Free PMC Article
    3. The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana. Xu F, et al. BMC Plant Biol, 2023 Mar 27. PMID 36973660, Free PMC Article
    4. Functional Relationship of Arabidopsis AOXs and PTOX Revealed via Transgenic Analysis. Wang D, et al. Front Plant Sci, 2021. PMID 34367216, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
      Title: The role of cyanoalanine synthase and alternative oxidase in promoting salt stress tolerance in Arabidopsis thaliana.
    2. The ability of AOX1a and AOX2 to substitute for PTOX in the correct physiological and developmental contexts is a striking example of the capacity of a mitochondrial protein to replace the function of a chloroplast protein.
      Title: Alternative oxidases (AOX1a and AOX2) can functionally substitute for plastid terminal oxidase in Arabidopsis chloroplasts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alternative oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables superoxide-generating NADPH oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquinol:oxygen oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    alternative oxidase 2
    NP_201226.2
    • alternative oxidase 2 (AOX2); CONTAINS InterPro DOMAIN/s: Alternative oxidase (InterPro:IPR002680); BEST Arabidopsis thaliana protein match is: alternative oxidase 1A (TAIR:AT3G22370.1); Has 1305 Blast hits to 1305 proteins in 244 species: Archae - 0; Bacteria - 111; Metazoa - 12; Fungi - 191; Plants - 373; Viruses - 0; Other Eukaryotes - 618 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25683770..25685731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125817.3 → NP_201226.2  alternative oxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201226.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22049, Q4PS98
      UniProtKB/TrEMBL
      A0A178UJF5, A0A5S9YGV6, A0A7G2FIP6
      Conserved Domains (1) summary
      PLN02478
      Location:19 → 353
      PLN02478; alternative oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22049.2

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