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    XF1 FAD/NAD(P)-binding oxidoreductase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842213, updated on 18-Sep-2024

    Summary

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    Official Symbol
    XF1
    Official Full Name
    FAD/NAD(P)-binding oxidoreductase family protein
    Primary source
    TAIR:AT1G58440
    Locus tag
    AT1G58440
    See related
    Araport:AT1G58440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DROUGHT HYPERSENSITIVE 2; DRY2; F9K23.3; F9K23_3; SQE1; SQUALENE EPOXIDASE 1
    Summary
    Encodes a putative protein that has been speculated, based on sequence similarities, to have squalene monooxygenase activity.
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    Genomic context

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    See XF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (21713842..21717380, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GDSL-like Lipase/Acylhydrolase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spectral phasor analysis reveals altered membrane order and function of root hair cells in Arabidopsis dry2/sqe1-5 drought hypersensitive mutant. Sena F, et al. Plant Physiol Biochem, 2017 Oct. PMID 28910707
    2. Identification of the Arabidopsis dry2/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species. Posé D, et al. Plant J, 2009 Jul. PMID 19309460
    3. Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity. Laranjeira S, et al. Mol Plant, 2015 Jul. PMID 25707755
    4. Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development. Rasbery JM, et al. J Biol Chem, 2007 Jun 8. PMID 17426032
    5. Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases. Etherington RD, et al. Plant Physiol, 2023 Oct 26. PMID 37427787, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases.
      Title: Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases.
    2. analysis of endomembrane dynamics showed that vesicle formation was affected in dry2/sqe1-5. Further analysis of proteins associated with sterol rich micro domains showed that dry2/sqe1-5 presented micro domains function altered.
      Title: Spectral phasor analysis reveals altered membrane order and function of root hair cells in Arabidopsis dry2/sqe1-5 drought hypersensitive mutant.
    3. SQE1 and SQE3 seem to be two functionally unequal redundant genes in the promotion of plant SQE activity in Arabidopsis
      Title: Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity.
    4. SQE1 encodes a squalene epoxidase protein involved in sterol biosynthesis, drought tolerance, and regulation of reactive oxygen species.
      Title: Identification of the Arabidopsis dry2/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_104624.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables squalene monooxygenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to ethylene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FAD/NAD(P)-binding oxidoreductase family protein
    NP_564734.1
    • XF1; FUNCTIONS IN: squalene monooxygenase activity; INVOLVED IN: response to water deprivation, sterol biosynthetic process; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Squalene epoxidase (InterPro:IPR013698); BEST Arabidopsis thaliana protein match is: squalene epoxidase 2 (TAIR:AT2G22830.1); Has 1994 Blast hits to 1990 proteins in 731 species: Archae - 43; Bacteria - 1249; Metazoa - 112; Fungi - 225; Plants - 178; Viruses - 0; Other Eukaryotes - 187 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21713842..21717380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104624.4 → NP_564734.1  FAD/NAD(P)-binding oxidoreductase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564734.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G1JSH7, Q9C649, Q9SM02
      UniProtKB/TrEMBL
      A0A178W2I2, A0A654EJB9
      Conserved Domains (1) summary
      PLN02985
      Location:58 → 525
      PLN02985; squalene monooxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SM02.1

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