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    BEN1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819146, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BEN1
    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT2G45400
    Locus tag
    AT2G45400
    See related
    Araport:AT2G45400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BRI1-5 ENHANCED 1; F4L23.9
    Summary
    involved in the regulation of brassinosteroid metabolic pathway
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    Genomic context

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    See BEN1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (18703772..18706401, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana. Yuan T, et al. Plant J, 2007 Jul. PMID 17521414
    2. Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase. Kekez M, et al. FEBS J, 2019 Feb. PMID 30570212
    3. Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking. Tanaka H, et al. Curr Biol, 2009 Mar 10. PMID 19230664
    4. Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana. Tanaka H, et al. PLoS Genet, 2013 May. PMID 23737757, Free PMC Article
    5. Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Shirley BW, et al. Plant Cell, 1992 Mar. PMID 1354004, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Seryl-tRNA Synthetase:BEN1 complex is one of the first protein complexes of plant aminoacyl-tRNA synthetase discovered so far, and is a rare example of an aminoacyl-tRNA synthetase interacting with an enzyme involved in primary or secondary metabolism.
      Title: Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase.
    2. BEN1 and BEN2 are collectively required for polar PIN localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes
      Title: Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana.
    3. Results identify BEN1 as the ARF GEF vesicle trafficking regulator mediating early endosomal traffic.
      Title: Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking.
    4. Analyses of brassinosteroid profiles demonstrated that BEN1 is indeed responsible for regulating the levels of several brassinosteroids, including typhasterol, castasterone and brassinolide.
      Title: BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001337127.1
    NM_001337128.1
    NM_001337129.1
    NM_130102.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in brassinosteroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brassinosteroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flavonoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of brassinosteroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_182064.1
    • BEN1; FUNCTIONS IN: coenzyme binding, oxidoreductase activity, acting on CH-OH group of donors, binding, catalytic activity; INVOLVED IN: regulation of brassinosteroid biosynthetic process, brassinosteroid metabolic process, response to light intensity, flavonoid biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: dihydroflavonol 4-reductase (TAIR:AT5G42800.1); Has 8852 Blast hits to 8839 proteins in 1531 species: Archae - 135; Bacteria - 3285; Metazoa - 357; Fungi - 858; Plants - 2633; Viruses - 7; Other Eukaryotes - 1577 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18703772..18706401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130102.5 → NP_182064.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22133
      UniProtKB/TrEMBL
      A0A5S9X770
      Conserved Domains (2) summary
      PLN02650
      Location:36 → 364
      PLN02650; dihydroflavonol-4-reductase
      cd08958
      Location:40 → 341
      FR_SDR_e; flavonoid reductase (FR), extended (e) SDRs

    2. NM_001337127.1 → NP_001323894.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYD5, A0A5S9X770

    3. NM_001337128.1 → NP_001323895.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYJ1, A0A5S9X770

    4. NM_001337129.1 → NP_001323896.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VQM9, A0A1P8AYJ2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22133.1

    Gene LinkOut

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