Taok1 TAO kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taok1provided by MGI
Official Full Name: TAO kinase 1provided by MGI
Primary source: MGI:MGI:1914490
See related: Ensembl:ENSMUSG00000017291 AllianceGenome:MGI:1914490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Psk2; Markk; Map3k16; 2810468K05Rik; D130018F14Rik
Summary: Predicted to enable several functions, including cytoskeletal protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in central nervous system neuron development. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; lung; nervous system; and submandibular gland primordium. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 7.8), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.64 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (77419988..77516185, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (77529162..77625359, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
Title: Taok1 haploinsufficiency leads to autistic-like behaviors in mice via the dorsal raphe nucleus.
Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
Title: Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.
Isolation and functional characterization of the rat Taok1 ortholog, and comparison to human TAOK1.
Title: Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.
Functional analysis of the human Tao1 ortholog.
Title: A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127913 (e-PCR)
- UniSTS:211223

NoName (e-PCR)
- UniSTS:234127

AI853701 (e-PCR)
- UniSTS:180933

RH136392 (e-PCR)
- UniSTS:210382

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein acetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase TAO1

Names: serine/threonine protein kinase TAO1 homolog; thousand and one amino acid protein 1

NP_001351062.1

EC 2.7.11.1

NP_001351063.1

EC 2.7.11.1

NP_659074.2

EC 2.7.11.1

XP_006533022.1

EC 2.7.11.1

XP_006533023.1

EC 2.7.11.1

XP_011247232.1

EC 2.7.11.1

XP_030101697.1

EC 2.7.11.1

XP_036012472.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364133.1 → NP_001351062.1 serine/threonine-protein kinase TAO1

Status: VALIDATED

Source sequence(s)

AL591136

Consensus CDS

CCDS36235.1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
NM_001364134.1 → NP_001351063.1 serine/threonine-protein kinase TAO1

Status: VALIDATED

Source sequence(s)

AL591136

Consensus CDS

CCDS36235.1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
NM_144825.3 → NP_659074.2 serine/threonine-protein kinase TAO1

See identical proteins and their annotated locations for NP_659074.2

Status: VALIDATED

Source sequence(s)

AK013386, AK143530, AK173156, BC034906, BE691513, CF164486, CN717576, CN717636, CN718413, CN721819, CN724017, CN724388

Consensus CDS

CCDS36235.1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Related

ENSMUSP00000055470.8, ENSMUST00000058496.8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

77419988..77516185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245837.2 → XP_030101697.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Related

ENSMUSP00000017435.5, ENSMUST00000017435.11

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_011248930.4 → XP_011247232.1 serine/threonine-protein kinase TAO1 isoform X1

See identical proteins and their annotated locations for XP_011247232.1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_006532960.4 → XP_006533023.1 serine/threonine-protein kinase TAO1 isoform X2

Conserved Domains (3) summary

COG0419
Location:194 → 625

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cl21453
Location:11 → 70

PKc_like; Protein Kinases, catalytic domain

cl27706
Location:656 → 713

Prion; Prion/Doppel alpha-helical domain
XM_006532959.5 → XP_006533022.1 serine/threonine-protein kinase TAO1 isoform X1

See identical proteins and their annotated locations for XP_006533022.1

UniProtKB/Swiss-Prot

Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7

UniProtKB/TrEMBL

B2RX66

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_036156579.1 → XP_036012472.1 serine/threonine-protein kinase TAO1 isoform X2

Conserved Domains (3) summary

COG0419
Location:194 → 625

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cl21453
Location:11 → 70

PKc_like; Protein Kinases, catalytic domain

cl27706
Location:656 → 713

Prion; Prion/Doppel alpha-helical domain