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    Ppp2r3a protein phosphatase 2, regulatory subunit B'', alpha [ Mus musculus (house mouse) ]

    Gene ID: 235542, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp2r3aprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', alphaprovided by MGI
    Primary source
    MGI:MGI:2442104
    See related
    Ensembl:ENSMUSG00000043154 AllianceGenome:MGI:2442104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730042E07; 3222402P14Rik; C530025M11Rik
    Summary
    Predicted to enable protein phosphatase regulator activity and protein-macromolecule adaptor activity. Predicted to be involved in several processes, including regulation of canonical Wnt signaling pathway; regulation of cell migration involved in somitogenic axis elongation; and somitogenesis. Predicted to be part of protein phosphatase type 2A complex. Is expressed in several structures, including genitourinary system; heart; liver; musculature; and spleen. Orthologous to human PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 13.2), CNS E18 (RPKM 5.5) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppp2r3a in Genome Data Viewer
    Location:
    9 E4; 9 53.19 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100982188..101129031, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101104989..101251832, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5097 Neighboring gene predicted gene, 46140 Neighboring gene MSL complex subunit 2 Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25048 Neighboring gene predicted gene 28979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. Zwaenepoel K, et al. BMC Genomics, 2008 Aug 20. PMID 18715506, Free PMC Article
    2. Protein phosphatase 2A PR130/B''alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling. Zwaenepoel K, et al. FASEB J, 2010 Feb. PMID 19825976
    3. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297, Free PMC Article
    4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29057

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration involved in somitogenic axis elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration involved in somitogenic axis elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic muscle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic muscle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somitogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somitogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
    NP_001154834.1
    NP_742156.2
    XP_006511767.1
    XP_017168836.1
    XP_017168837.1
    XP_017168838.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161362.3 → NP_001154834.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_001154834.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK042943, AK076163, AK132175, BU758090, CJ100577, CX220062
      Consensus CDS
      CCDS52900.1
      UniProtKB/TrEMBL
      B2RXC8
      Related
      ENSMUSP00000075327.6, ENSMUST00000075941.12
      Conserved Domains (2) summary
      pfam13499
      Location:899 → 1000
      EF-hand_7; EF-hand domain pair
      pfam17958
      Location:795 → 884
      EF-hand_13; EF-hand domain

    2. NM_172144.3 → NP_742156.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_742156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a distinct translation start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK132175, BU758090, CK621911, CX220062
      Consensus CDS
      CCDS52899.1
      UniProtKB/TrEMBL
      G3X9E8, Q3V1Y6
      Related
      ENSMUSP00000069688.8, ENSMUST00000066773.9
      Conserved Domains (1) summary
      pfam13499
      Location:282 → 380
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      100982188..101129031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313347.2 → XP_017168836.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1

      UniProtKB/TrEMBL
      B2RXC8
      Conserved Domains (2) summary
      pfam13499
      Location:899 → 1000
      EF-hand_7; EF-hand domain pair
      pfam17958
      Location:795 → 884
      EF-hand_13; EF-hand domain

    2. XM_006511704.5 → XP_006511767.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X4

      UniProtKB/TrEMBL
      Q3V1Y6
      Conserved Domains (2) summary
      pfam13499
      Location:236 → 337
      EF-hand_7; EF-hand domain pair
      pfam17958
      Location:132 → 221
      EF-hand_13; EF-hand domain

    3. XM_017313349.2 → XP_017168838.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3

      Conserved Domains (2) summary
      pfam13499
      Location:899 → 1000
      EF-hand_7; EF-hand domain pair
      pfam17958
      Location:795 → 884
      EF-hand_13; EF-hand domain

    4. XM_017313348.2 → XP_017168837.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2

      Conserved Domains (2) summary
      pfam13499
      Location:899 → 1000
      EF-hand_7; EF-hand domain pair
      pfam17958
      Location:795 → 884
      EF-hand_13; EF-hand domain

    RNA

    1. XR_001778885.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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