Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
HIV-1 Nef downregulates the expression of eukaryotic translation initiation factor 5A (EIF5A) protein in Nef-transfected SupT1 cells |
PubMed
|
Rev
|
rev
|
eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export |
PubMed
|
|
rev
|
eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev |
PubMed
|
|
rev
|
eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA |
PubMed
|
|
rev
|
eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity |
PubMed
|
|
rev
|
eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev |
PubMed
|
|
rev
|
eIF-5A interacts with the activation domain of Rev (amino acids 75-83) |
PubMed
|
retropepsin
|
gag-pol
|
Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease |
PubMed
|
Go to the HIV-1, Human Interaction Database