Rbbp9 RB binding protein 9, serine hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbbp9provided by RGD
Official Full Name: RB binding protein 9, serine hydrolaseprovided by RGD
Primary source: RGD:3542
See related: EnsemblRapid:ENSRNOG00000007972 AllianceGenome:RGD:3542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hydrolase activity. Involved in regulation of cell population proliferation. Predicted to be located in nucleoplasm. Orthologous to human RBBP9 (RB binding protein 9, serine hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 126.8), Adrenal (RPKM 104.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (152378426..152392370, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (131925095..131939042, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (138701579..138708332, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to nematode	ISO Inferred from Sequence Orthology more info
involved_in type II pneumocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type II pneumocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine hydrolase RBBP9

Names: B5T-overexpressed gene protein; RBBP-9; putative hydrolase RBBP9; retinoblastoma-binding protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019219.3 → NP_062092.2 serine hydrolase RBBP9

See identical proteins and their annotated locations for NP_062092.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88350, Q3T1H7

UniProtKB/TrEMBL

A0A8L2Q4I8, A6K763

Related

ENSRNOP00000010678.5, ENSRNOT00000010678.6

Conserved Domains (1) summary

cl21494
Location:8 → 173

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

152378426..152392370 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104444.1 → XP_038960372.1 serine hydrolase RBBP9 isoform X1

Conserved Domains (1) summary

cl21494
Location:1 → 130

Abhydrolase; alpha/beta hydrolases
XM_063283215.1 → XP_063139285.1 serine hydrolase RBBP9 isoform X1
XM_039104445.2 → XP_038960373.1 serine hydrolase RBBP9 isoform X2

Conserved Domains (1) summary

cl21494
Location:1 → 115

Abhydrolase; alpha/beta hydrolases