Foxa2 forkhead box A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxa2provided by RGD
Official Full Name: forkhead box A2provided by RGD
Primary source: RGD:2808
See related: EnsemblRapid:ENSRNOG00000013133 AllianceGenome:RGD:2808
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hnf3b
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to insulin. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 86.3), Liver (RPKM 70.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (155923305..155927508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (135470123..135474326, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (142383084..142387493)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FXR controls insulin content by regulating Foxa2-mediated insulin transcription.
Title: FXR controls insulin content by regulating Foxa2-mediated insulin transcription.
FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis.
Title: FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis.
Low FOXA2 expression is associated with congenital diaphragmatic hernia.
Title: MiR-130a-5p/Foxa2 axis modulates fetal lung development in congenital diaphragmatic hernia by activating the Shh/Gli1 signaling pathway.
FOXA2 knockdown significantly increased osteoblast-specific gene expression, the number of mineral deposits and alkaline phosphatase activity, whereas FOXA2 overexpression inhibited osteogenesis-specific activities. Moreover, extracellular signal-regulated protein kinase (ERK) signalling was upregulated following knockdown of FOXA2.
Title: Knockdown of FOXA2 enhances the osteogenic differentiation of bone marrow-derived mesenchymal stem cells partly via activation of the ERK signalling pathway.
The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)...It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases
Title: Expression of Lung Surfactant Proteins SP-B and SP-C and Their Regulatory Factors in Fetal Lung of GDM Rats.
MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia.
Title: MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells.
Foxa1 and Foxa2 control glucagon biosynthesis and secretion as well as alpha-cell differentiation with both common and unique target genes.
Title: Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion.
HNF-1alpha, HNF-4alpha and FOXA2 transcriptional factors are involved in diabetes-induced overexpression of Slc2a2 gene in the liver and kidney.
Title: Hepatocyte nuclear factors 1α/4α and forkhead box A2 regulate the solute carrier 2A2 (Slc2a2) gene expression in the liver and kidney of diabetic rats.
Sumoylation increased the transcriptional activity of FOXA2.
Title: Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.
IL-13 down-regulates mucus secretion via STAT6-FOXA2 pathway in vitro.
Title: [Molecular mechanism of interleukin-13-induced mucus hypersecretion in rat airway].

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

UniSTS:474762 (e-PCR)
- UniSTS:474762

Foxa2 (e-PCR), detects polymorphism
- UniSTS:474762

Foxa2 (e-PCR), detects polymorphism
- UniSTS:464791

PMC86995P1 (e-PCR)
- UniSTS:273572

NoName (e-PCR)
- UniSTS:547510

Foxa2 (e-PCR), detects polymorphism
- UniSTS:547510

Foxa2 (e-PCR), detects polymorphism
- UniSTS:547832

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anatomical structure morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation in hindbrain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectoderm formation	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in endocrine pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glucose mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mesendoderm development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gastrulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primitive streak formation	ISO Inferred from Sequence Orthology more info
involved_in primitive streak formation	ISO Inferred from Sequence Orthology more info
involved_in primitive streak formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somite rostral/caudal axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hepatocyte nuclear factor 3-beta

Names: HNF-3-beta; HNF-3B; forkhead box protein A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399085.1 → NP_001386014.1 hepatocyte nuclear factor 3-beta isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

Conserved Domains (4) summary

COG5025
Location:164 → 380

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam08430
Location:23 → 164

Forkhead_N; Forkhead N-terminal region

pfam09354
Location:381 → 454

HNF_C; HNF3 C-terminal domain

cd20039
Location:163 → 264

FH_FOXA2; Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins
NM_012743.2 → NP_036875.2 hepatocyte nuclear factor 3-beta isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P32182

UniProtKB/TrEMBL

A6K7B1, G3V7Q2

Related

ENSRNOP00000017742.1, ENSRNOT00000017742.5

Conserved Domains (4) summary

COG5025
Location:158 → 374

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam08430
Location:17 → 158

Forkhead_N; Forkhead N-terminal region

pfam09354
Location:375 → 448

HNF_C; HNF3 C-terminal domain

cd20039
Location:157 → 258

FH_FOXA2; Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins