Lamp1 lysosomal-associated membrane protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamp1provided by RGD
Official Full Name: lysosomal-associated membrane protein 1provided by RGD
Primary source: RGD:2989
See related: EnsemblRapid:ENSRNOG00000019629 AllianceGenome:RGD:2989
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LGP120
Summary: Predicted to enable enzyme binding activity; ion channel inhibitor activity; and protein domain specific binding activity. Involved in autophagic cell death. Located in several cellular components, including cytoplasmic vesicle; lysosome; and neuronal cell body. Is active in glutamatergic synapse; postsynapse; and synaptic vesicle membrane. Orthologous to human LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 3924.5), Lung (RPKM 1610.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (83058131..83082843, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (76355982..76380700, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (81689576..81714341, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings documented that circ-LAMP1 might be an oncogene in T-cell lymphoblastic lymphoma (T-LBL), which might be useful in developing promising therapies for T-LBL.
Title: Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression.
dihydrolipoic acid (DHLA) treatment improved neurofunction and alleviated inflammation through the lysosome-associated membrane protein-1/CaMKII/TAK1 pathway in early brain injury after subarachnoid hemorrhage (SAH). DHLA may provide a promising treatment to alleviate early brain injury after SAH.
Title: Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC disease and uncovers new targets for therapeutic approaches.
Title: Reversal of Pathologic Lipid Accumulation in NPC1-Deficient Neurons by Drug-Promoted Release of LAMP1-Coated Lamellar Inclusions.
conclude that status epilepticus not only increased autophagosomal abundance, but also lysosomal activities and a massive accumulation of LAMP1 in axons of dentate gyrus. This could support the hypothesis that the marked increased autophagosomal abundance in cytosol reflects an increase in the autophagic activity more than an inhibition of autophagosomal clearance
Title: Axonal Accumulation of Lysosomal-Associated Membrane Protein 1 (LAMP1) Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224778 (e-PCR)
- UniSTS:224778

RH137106 (e-PCR)
- UniSTS:219194

RH142299 (e-PCR)
- UniSTS:231546

Lamp1 (e-PCR), detects polymorphism
- UniSTS:143755

UniSTS:143756 (e-PCR)
- UniSTS:143756

Lamp1 (e-PCR), detects polymorphism
- UniSTS:143756

BI282190 (e-PCR)
- UniSTS:249759

J03881 (e-PCR)
- UniSTS:159736

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ion channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ion channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ion channel inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in autophagic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to organelle	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to organelle	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in granzyme-mediated programmed cell death signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen acidification	IEA Inferred from Electronic Annotation more info
involved_in lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
involved_in lysosomal lumen acidification	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of natural killer cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of organelle transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in regulation of organelle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in alveolar lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in autolysosome	IEA Inferred from Electronic Annotation more info
located_in autolysosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule membrane	IEA Inferred from Electronic Annotation more info
located_in cytolytic granule membrane	ISO Inferred from Sequence Orthology more info
located_in cytolytic granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagolysosome membrane	IEA Inferred from Electronic Annotation more info
located_in phagolysosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosome-associated membrane glycoprotein 1

Names: 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LAMP-1; LGP-120; Lysosomal associated membrane protein 1 (120 kDa); lysosomal membrane glycoprotein 1; lysosome-associated membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012857.2 → NP_036989.1 lysosome-associated membrane glycoprotein 1 precursor

See identical proteins and their annotated locations for NP_036989.1

Status: PROVISIONAL

Source sequence(s)

M34959

UniProtKB/Swiss-Prot

P14562, P97620

UniProtKB/TrEMBL

A0A0U1RRW1, A0A6F8P9J1, A0A8L2UK78, A6IWJ4

Related

ENSRNOP00000026580.6, ENSRNOT00000026580.8

Conserved Domains (2) summary

cd12087
Location:372 → 401

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam01299
Location:107 → 407

Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

83058131..83082843 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599994.3 → XP_017455483.1 lysosome-associated membrane glycoprotein 1 isoform X1

UniProtKB/Swiss-Prot

P14562, P97620

UniProtKB/TrEMBL

A0A0U1RRW1, A0A6F8P9J1, A0A8L2UK78, A6IWJ4

Conserved Domains (2) summary

cd12087
Location:372 → 401

TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases

pfam01299
Location:107 → 407

Lamp; Lysosome-associated membrane glycoprotein (Lamp)