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    Fcrla Fc receptor-like A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fcrlaprovided by RGD
    Official Full Name
    Fc receptor-like Aprovided by RGD
    Primary source
    RGD:1306176
    See related
    EnsemblRapid:ENSRNOG00000003136 AllianceGenome:RGD:1306176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fcrlm1; RGD1306176
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human FCRLA (Fc receptor like A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 297.2), Thymus (RPKM 32.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fcrla in Genome Data Viewer
    Location:
    13q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (85693177..85702875, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83160453..83170170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89296570..89306219, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096314 Neighboring gene Fc receptor-like B Neighboring gene U1 spliceosomal RNA Neighboring gene Fc gamma receptor 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new Fc receptor homolog, FREB2, found in germinal center B cells. Wilson TJ, et al. Genes Immun, 2005 Jun. PMID 15815692
    2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like A
    Names
    Fc receptor homolog expressed in B cells
    fc receptor-like and mucin-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100682.1 → NP_001094152.1  Fc receptor-like A precursor

      See identical proteins and their annotated locations for NP_001094152.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158820
      UniProtKB/Swiss-Prot
      Q3B8P2
      UniProtKB/TrEMBL
      A6IDQ8, B0BNH2
      Related
      ENSRNOP00000004183.5, ENSRNOT00000004183.8
      Conserved Domains (3) summary
      smart00410
      Location:98 → 172
      IG_like; Immunoglobulin like
      pfam13927
      Location:178 → 249
      Ig_3; Immunoglobulin domain
      cl11960
      Location:86 → 172
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      85693177..85702875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090795.2 → XP_038946723.1  Fc receptor-like A isoform X1

      UniProtKB/TrEMBL
      A6IDQ8, A6IDQ9
      Conserved Domains (3) summary
      smart00409
      Location:190 → 258
      IG; Immunoglobulin
      cd00096
      Location:86 → 90
      Ig; Ig strand A [structural motif]
      cl11960
      Location:86 → 172
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B8P2.2 GenPept UniProtKB/Swiss-Prot:Q3B8P2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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