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    Hnrnph3 heterogeneous nuclear ribonucleoprotein H3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361838, updated on 9-Dec-2024

    Summary

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    Symbol
    Hnrnph3provided by RGD
    Full Name
    heterogeneous nuclear ribonucleoprotein H3provided by RGD
    Primary source
    RGD:1310019
    See related
    EnsemblRapid:ENSRNOG00000048193 AllianceGenome:RGD:1310019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrph3
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in epithelial cell differentiation and regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 149.3), Spleen (RPKM 133.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnph3 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25619540..25624397)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25616400..25625814)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27167926..27178172)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis-like protein domain containing 1 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene RUN and FYVE domain containing 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene solute carrier family 25 member 16 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mauger DM, et al. Mol Cell Biol, 2008 Sep. PMID 18573884, Free PMC Article
    2. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Buhrke T, et al. Dev Growth Differ, 2011 Apr. PMID 21492153
    3. PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. Todd MA, et al. J Proteome Res, 2012 Aug 3. PMID 22720776
    4. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H3
    Names
    heterogeneous nuclear ribonucleoprotein H3 (2H9)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108532.1 → NP_001102002.1  heterogeneous nuclear ribonucleoprotein H3

      See identical proteins and their annotated locations for NP_001102002.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473988
      UniProtKB/TrEMBL
      A6JKZ7, D4ABK7
      Related
      ENSRNOP00000029804.5, ENSRNOT00000032600.7
      Conserved Domains (2) summary
      cd12735
      Location:195 → 269
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      25619540..25624397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256380.5 → XP_006256442.2  heterogeneous nuclear ribonucleoprotein H3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JVA2, A6JKZ9, D4ABK7
      Related
      ENSRNOP00000069405.3, ENSRNOT00000077525.3
      Conserved Domains (2) summary
      cd12735
      Location:180 → 254
      RRM3_hnRNPH3; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
      cd12732
      Location:1 → 93
      RRM2_hnRNPH3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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