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    Wasf3 WASP family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wasf3provided by RGD
    Official Full Name
    WASP family member 3provided by RGD
    Primary source
    RGD:1592807
    See related
    EnsemblRapid:ENSRNOG00000048898 AllianceGenome:RGD:1592807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in cytoskeleton organization; modification of postsynaptic actin cytoskeleton; and regulation of cell shape. Predicted to act upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Predicted to be located in glial cell projection and lamellipodium. Predicted to be active in glutamatergic synapse and postsynapse. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 98.3), Kidney (RPKM 29.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wasf3 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13675642..13774648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8563805..8660799, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10297896..10391014, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095929 Neighboring gene uncharacterized LOC134481262 Neighboring gene uncharacterized LOC134481263 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120095890 Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene cyclin-dependent kinase 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization. Pilpel Y, et al. J Neurochem, 2005 Dec. PMID 16190876
    2. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. Kim HJ, et al. J Neurosci, 2006 May 24. PMID 16723544, Free PMC Article
    3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modification of postsynaptic actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding protein WASF3
    Names
    WAS protein family, member 3
    wiskott-Aldrich syndrome protein family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427154.2 → NP_001414083.1  actin-binding protein WASF3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1D0, M0R7F3
      Related
      ENSRNOP00000065380.3, ENSRNOT00000071567.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      13675642..13774648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271653.1 → XP_063127723.1  actin-binding protein WASF3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G8L2
      Related
      ENSRNOP00000081893.1, ENSRNOT00000119900.2

    2. XM_039089936.2 → XP_038945864.1  actin-binding protein WASF3 isoform X1

      UniProtKB/TrEMBL
      A6K1D0, M0R7F3
      Conserved Domains (2) summary
      cd21762
      Location:454 → 457
      WH2; actin-binding sequence [structural motif]
      cl41728
      Location:437 → 502
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    3. XM_063271655.1 → XP_063127725.1  actin-binding protein WASF3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G8L2

    4. XM_063271652.1 → XP_063127722.1  actin-binding protein WASF3 isoform X1

      UniProtKB/TrEMBL
      A6K1D0, M0R7F3

    5. XM_063271654.1 → XP_063127724.1  actin-binding protein WASF3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G8L2

    6. XM_039089938.2 → XP_038945866.1  actin-binding protein WASF3 isoform X3

      Conserved Domains (1) summary
      cd22073
      Location:224 → 289
      WH2_WAVE-3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family Member 3 (WASP-3 or WAVE3)

    RNA

    1. XR_010056418.1 RNA Sequence

    2. XR_010056416.1 RNA Sequence

    3. XR_010056417.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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