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    Mau2 MAU2 sister chromatid cohesion factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mau2provided by RGD
    Official Full Name
    MAU2 sister chromatid cohesion factorprovided by RGD
    Primary source
    RGD:1308759
    See related
    EnsemblRapid:ENSRNOG00000020526 AllianceGenome:RGD:1308759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308759
    Summary
    Predicted to enable cohesin loader activity and double-stranded DNA binding activity. Predicted to be involved in maintenance of mitotic sister chromatid cohesion. Predicted to be located in chromatin and nuclear body. Predicted to be part of Scc2-Scc4 cohesin loading complex. Orthologous to human MAU2 (MAU2 sister chromatid cohesion factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 168.4), Thymus (RPKM 135.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mau2 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19417812..19448922)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19383847..19414996)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21132115..21163257)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transmembrane 6 superfamily member 2 Neighboring gene SURP and G patch domain containing 1 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene testis-specific serine kinase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22628566, Free PMC Article
    2. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. Seitan VC, et al. PLoS Biol, 2006 Jul. PMID 16802858, Free PMC Article
    3. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Watrin E, et al. Curr Biol, 2006 May 9. PMID 16682347
    4. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Remeseiro S, et al. Biochim Biophys Acta, 2013 Dec. PMID 23920377, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cohesin loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SMC loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMC loading complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Scc2-Scc4 cohesin loading complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAU2 chromatid cohesion factor homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106077.4 → NP_001099547.2  MAU2 chromatid cohesion factor homolog isoform 1

      See identical proteins and their annotated locations for NP_001099547.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3Z8G8
      Related
      ENSRNOP00000027846.9, ENSRNOT00000027846.9
      Conserved Domains (2) summary
      sd00006
      Location:71 → 100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30 → 576
      Cohesin_load; Cohesin loading factor

    2. NM_001277306.1 → NP_001264235.1  MAU2 chromatid cohesion factor homolog isoform 2

      See identical proteins and their annotated locations for NP_001264235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI045736, JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2JZP5, A6KA97
      Related
      ENSRNOP00000071129.1, ENSRNOT00000084243.3
      Conserved Domains (1) summary
      pfam10345
      Location:30 → 98
      Cohesin_load; Cohesin loading factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19417812..19448922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252877.5 → XP_006252939.1  MAU2 chromatid cohesion factor homolog isoform X1

      See identical proteins and their annotated locations for XP_006252939.1

      UniProtKB/TrEMBL
      A6KA95, D3Z8G8
      Conserved Domains (2) summary
      sd00006
      Location:71 → 100
      TPR; TPR repeat [structural motif]
      pfam10345
      Location:30 → 575
      Cohesin_load; Cohesin loading factor

    2. XM_063275189.1 → XP_063131259.1  MAU2 chromatid cohesion factor homolog isoform X2

    RNA

    1. XR_005494570.2 RNA Sequence

    2. XR_005494572.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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