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    P4ha3 prolyl 4-hydroxylase subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P4ha3provided by RGD
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 3provided by RGD
    Primary source
    RGD:735150
    See related
    EnsemblRapid:ENSRNOG00000017118 AllianceGenome:RGD:735150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 48.6), Thymus (RPKM 34.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P4ha3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164040852..164075922)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154628723..154663779)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165295835..165330922)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100912071 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 3 Neighboring gene phosphoglucomutase 2-like 1 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene uncharacterized LOC120099892 Neighboring gene C2 domain containing 3 centriole elongation regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. Kukkola L, et al. J Biol Chem, 2003 Nov 28. PMID 14500733
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of collagen prolyl 4-hydroxylase isoenzyme 3, its expression and catalytic properties
      Title: Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of procollagen-proline 4-dioxygenase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-3
    Names
    4-PH alpha-3
    collagen prolyl 4-hydroxylase alpha III subunit
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
    procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
    prolyl 4-hydroxylase, alpha polypeptide III
    NP_942070.1
    XP_038938408.1
    XP_063123235.1
    XP_063123241.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198775.1 → NP_942070.1  prolyl 4-hydroxylase subunit alpha-3 precursor

      See identical proteins and their annotated locations for NP_942070.1

      Status: PROVISIONAL

      Source sequence(s)
      AY313450
      UniProtKB/Swiss-Prot
      Q6W3E9
      UniProtKB/TrEMBL
      F1LQ79
      Conserved Domains (2) summary
      smart00702
      Location:356 → 528
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:33 → 159
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164040852..164075922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267171.1 → XP_063123241.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

      UniProtKB/TrEMBL
      F1LQ79
      Related
      ENSRNOP00000094149.1, ENSRNOT00000096221.2

    2. XM_039082480.2 → XP_038938408.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

      UniProtKB/TrEMBL
      F1LQ79
      Related
      ENSRNOP00000049901.3, ENSRNOT00000046943.4
      Conserved Domains (2) summary
      smart00702
      Location:356 → 478
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:34 → 108
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_063267165.1 → XP_063123235.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

      UniProtKB/TrEMBL
      F1LQ79
      Related
      ENSRNOP00000106965.1, ENSRNOT00000157481.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6W3E9.1 GenPept UniProtKB/Swiss-Prot:Q6W3E9

    Gene LinkOut

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