Glce glucuronic acid epimerase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Glceprovided by RGD
Official Full Name: glucuronic acid epimeraseprovided by RGD
Primary source: RGD:1565253
See related: EnsemblRapid:ENSRNOG00000025372 AllianceGenome:RGD:1565253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565253
Summary: Predicted to enable calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in negative regulation of cell projection organization; positive regulation of SMAD protein signal transduction; and positive regulation of cell population proliferation. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Orthologous to human GLCE (glucuronic acid epimerase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 156.8), Thymus (RPKM 146.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (71441607..71507639, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (62546104..62612144, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (67006588..67073723, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The function of GLCE in neuritogenesis via SMAD/ID3 signalling was studied via mutagenesis and gene silencing studies.
Title: GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling.

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General gene information

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Markers

RH91714 (e-PCR)
- UniSTS:90296

AI747411 (e-PCR)
- UniSTS:179918

BI274218 (e-PCR)
- UniSTS:249055

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables heparosan-N-sulfate-glucuronate 5-epimerase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables racemase and epimerase activity, acting on carbohydrates and derivatives	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: D-glucuronyl C5-epimerase

Names: glucuronyl C5-epimerase

NP_001414556.1

EC 5.1.3.12

XP_038938365.1

EC 5.1.3.12

XP_063121830.1

EC 5.1.3.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427627.1 → NP_001414556.1 D-glucuronyl C5-epimerase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J572, D3ZIK0

Related

ENSRNOP00000037789.4, ENSRNOT00000038641.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

71441607..71507639 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265760.1 → XP_063121830.1 D-glucuronyl C5-epimerase isoform X1

UniProtKB/TrEMBL

A6J572, D3ZIK0
XM_039082437.2 → XP_038938365.1 D-glucuronyl C5-epimerase isoform X1

UniProtKB/TrEMBL

A6J572, D3ZIK0

Conserved Domains (1) summary

pfam06662
Location:417 → 608

C5-epim_C; D-glucuronyl C5-epimerase C-terminus