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    Tomm34 translocase of outer mitochondrial membrane 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tomm34provided by RGD
    Official Full Name
    translocase of outer mitochondrial membrane 34provided by RGD
    Primary source
    RGD:1309029
    See related
    EnsemblRapid:ENSRNOG00000029799 AllianceGenome:RGD:1309029
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heat shock protein binding activity. Predicted to be involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human TOMM34 (translocase of outer mitochondrial membrane 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 142.4), Thymus (RPKM 99.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tomm34 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173148737..173165689, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152729345..152746295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160448294..160465143, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene serine/threonine kinase 4 Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 1 Neighboring gene WAP four-disulfide core domain 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. hTom34: a novel translocase for the import of proteins into human mitochondria. Nuttall SD, et al. DNA Cell Biol, 1997 Sep. PMID 9324309
    2. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. Young JC, et al. J Biol Chem, 1998 Jul 17. PMID 9660753
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM34
    Names
    translocase of outer membrane 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044244.2 → NP_001037709.1  mitochondrial import receptor subunit TOM34

      See identical proteins and their annotated locations for NP_001037709.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105768
      UniProtKB/Swiss-Prot
      Q3KRD5
      UniProtKB/TrEMBL
      A0A8L2QQ52, A6JX57
      Related
      ENSRNOP00000103709.1, ENSRNOT00000129301.1
      Conserved Domains (2) summary
      TIGR00990
      Location:11 → 294
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173148737..173165689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283870.1 → XP_063139940.1  mitochondrial import receptor subunit TOM34 isoform X2

    2. XM_006235585.5 → XP_006235647.1  mitochondrial import receptor subunit TOM34 isoform X1

      See identical proteins and their annotated locations for XP_006235647.1

      UniProtKB/TrEMBL
      A0A8I6AAW4, A0A8L2QQ52, A6JX58
      Related
      ENSRNOP00000089109.1, ENSRNOT00000115450.2
      Conserved Domains (3) summary
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:229 → 260
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:192 → 257
      TPR_11; TPR repeat

    RNA

    1. XR_005501898.2 RNA Sequence

      Related
      ENSRNOT00000121111.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRD5.1 GenPept UniProtKB/Swiss-Prot:Q3KRD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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