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    Bfar bifunctional apoptosis regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304709, updated on 9-Dec-2024

    Summary

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    Symbol
    Bfarprovided by RGD
    Full Name
    bifunctional apoptosis regulatorprovided by RGD
    Primary source
    RGD:1304791
    See related
    EnsemblRapid:ENSRNOG00000003151 EnsemblRapid:ENSRNOG00000084995 AllianceGenome:RGD:1304791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305537
    Summary
    Predicted to enable caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to act upstream of or within negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human BFAR (bifunctional apoptosis regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 297.1), Muscle (RPKM 158.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bfar in Genome Data Viewer
    Location:
    10q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2059189..2092207)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (1552019..1585040)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (1464783..1497653)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547286 Neighboring gene uncharacterized LOC120095007 Neighboring gene poly(A)-specific ribonuclease Neighboring gene dynein light chain LC8-type 1 like Neighboring gene phospholipase A2, group X Neighboring gene large ribosomal subunit protein uL10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins. Zhang H, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10716992, Free PMC Article
    2. Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress. Rong J, et al. J Biol Chem, 2011 Jan 14. PMID 21068390, Free PMC Article
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables caspase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional apoptosis regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013125.2 → NP_001013143.1  bifunctional apoptosis regulator

      See identical proteins and their annotated locations for NP_001013143.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
      Source sequence(s)
      BC087103, FM033098, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q5PQN2
      Related
      ENSRNOP00000004217.7, ENSRNOT00000004217.10
      Conserved Domains (2) summary
      cd09513
      Location:179 → 249
      SAM_BAR; SAM domain of BAR subfamily
      cd16497
      Location:32 → 77
      RING-HC_BAR; RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)

    RNA

    1. NR_138253.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      JAXUCZ010000010
      Related
      ENSRNOT00000126660.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      2059189..2092207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086234.2 → XP_038942162.1  bifunctional apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y9Y1
      Related
      ENSRNOP00000101903.1, ENSRNOT00000134333.1
      Conserved Domains (2) summary
      cd16497
      Location:32 → 77
      RING-HC_BAR; RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)
      cl15755
      Location:98 → 124
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_063269266.1 → XP_063125336.1  bifunctional apoptosis regulator isoform X1

      UniProtKB/Swiss-Prot
      Q5PQN2
      Related
      ENSRNOP00000078143.2, ENSRNOT00000099882.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQN2.1 GenPept UniProtKB/Swiss-Prot:Q5PQN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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