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    Rabggta Rab geranylgeranyltransferase subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rabggtaprovided by RGD
    Official Full Name
    Rab geranylgeranyltransferase subunit alphaprovided by RGD
    Primary source
    RGD:621697
    See related
    EnsemblRapid:ENSRNOG00000030483 AllianceGenome:RGD:621697
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Rab geranylgeranyltransferase activity and small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 81.2), Heart (RPKM 75.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rabggta in Genome Data Viewer
    Location:
    15p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33176268..33183320, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29206328..29213398, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34393419..34400466, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2 Neighboring gene dehydrogenase/reductase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Arora DK, et al. Islets, 2012 Sep-Oct. PMID 23114750, Free PMC Article
    2. Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex. Guo Z, et al. Angew Chem Int Ed Engl, 2008. PMID 18399557
    3. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, et al. Structure, 2000 Mar 15. PMID 10745007
    4. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article
    5. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, et al. J Biol Chem, 1993 Jun 5. PMID 8505342

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rab geranylgeranyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein geranylgeranylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    geranylgeranyl transferase type-2 subunit alpha
    Names
    Rab geranylgeranyl transferase, a subunit
    Rab geranylgeranyltransferase alpha
    Rab geranylgeranyltransferase, alpha subunit
    geranylgeranyl transferase type II subunit alpha
    rab GG transferase alpha
    rab GGTase alpha
    rab geranyl-geranyltransferase subunit alpha
    NP_113842.1
    XP_006252071.1
    XP_006252072.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031654.2 → NP_113842.1  geranylgeranyl transferase type-2 subunit alpha

      See identical proteins and their annotated locations for NP_113842.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086547
      UniProtKB/Swiss-Prot
      Q08602
      UniProtKB/TrEMBL
      A0A8I6GJ12, A6KH43
      Related
      ENSRNOP00000091502.2, ENSRNOT00000108610.2
      Conserved Domains (4) summary
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      cd21340
      Location:444 → 547
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl40684
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33176268..33183320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252010.5 → XP_006252072.1  geranylgeranyl transferase type-2 subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006252072.1

      UniProtKB/Swiss-Prot
      Q08602
      UniProtKB/TrEMBL
      A0A8I6GJ12, A6KH43
      Related
      ENSRNOP00000049261.5, ENSRNOT00000048455.6
      Conserved Domains (4) summary
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      cd21340
      Location:444 → 547
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl40684
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat

    2. XM_006252009.5 → XP_006252071.1  geranylgeranyl transferase type-2 subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006252071.1

      UniProtKB/Swiss-Prot
      Q08602
      UniProtKB/TrEMBL
      A0A8I6GJ12, A6KH43
      Conserved Domains (4) summary
      sd00031
      Location:443 → 461
      LRR_1; leucine-rich repeat [structural motif]
      pfam07711
      Location:247 → 346
      RabGGT_insert; Rab geranylgeranyl transferase alpha-subunit, insert domain
      cd21340
      Location:444 → 547
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl40684
      Location:1 → 237
      PPTA; Protein prenyltransferase alpha subunit repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08602.1 GenPept UniProtKB/Swiss-Prot:Q08602

    Gene LinkOut

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