U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stk36 serine/threonine kinase 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301516, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Stk36provided by RGD
    Official Full Name
    serine/threonine kinase 36provided by RGD
    Primary source
    RGD:1307318
    See related
    EnsemblRapid:ENSRNOG00000016913 AllianceGenome:RGD:1307318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Predicted to be involved in several processes, including axoneme assembly; positive regulation of smoothened signaling pathway; and regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 66.1), Lung (RPKM 29.1) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Stk36 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (83625905..83652785)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76176922..76204423)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (81880175..81908014)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene phospholipase C, delta 4 Neighboring gene zinc finger protein 142 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene uncharacterized LOC134480595 Neighboring gene tubulin tyrosine ligase like 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Maloveryan A, et al. J Cell Commun Signal, 2007 Dec. PMID 18600476, Free PMC Article
    2. Gli regulation by the opposing activities of fused and suppressor of fused. Murone M, et al. Nat Cell Biol, 2000 May. PMID 10806483
    3. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Merchant M, et al. Mol Cell Biol, 2005 Aug. PMID 16055717, Free PMC Article
    4. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Wilson CW, et al. Nature, 2009 May 7. PMID 19305393, Free PMC Article
    5. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/threonine-protein kinase 36
    Names
    serine/threonine kinase 36 (fused homolog, Drosophila)
    NP_001167457.1
    XP_006245236.1
    XP_063123044.1
    XP_063123045.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173986.1 → NP_001167457.1  serine/threonine-protein kinase 36

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZA65
      Related
      ENSRNOP00000022839.7, ENSRNOT00000022839.9
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      83625905..83652785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245174.5 → XP_006245236.1  serine/threonine-protein kinase 36 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8C3, D3ZA65
      Related
      ENSRNOP00000077934.1, ENSRNOT00000112437.2
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    2. XM_063266974.1 → XP_063123044.1  serine/threonine-protein kinase 36 isoform X2

      UniProtKB/TrEMBL
      D3ZA65

    3. XM_063266975.1 → XP_063123045.1  serine/threonine-protein kinase 36 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools