Pla2g2f phospholipase A2, group IIF [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g2fprovided by RGD
Official Full Name: phospholipase A2, group IIFprovided by RGD
Primary source: RGD:1597305
See related: AllianceGenome:RGD:1597305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in arachidonate metabolic process; glycerophospholipid metabolic process; and negative regulation of T cell proliferation. Predicted to act upstream of or within phospholipid metabolic process. Predicted to be located in extracellular region. Orthologous to human PLA2G2F (phospholipase A2 group IIF). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 239.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (156270077..156276464, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (150986788..150993175, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (157192047..157217265, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group IIF secretory phospholipase A2

NP_001103057.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109587.1 → NP_001103057.1 group IIF secretory phospholipase A2

See identical proteins and their annotated locations for NP_001103057.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6ITI5, D3ZLB5

Conserved Domains (1) summary

cd00125
Location:63 → 180

PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...