Nmt2 N-myristoyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmt2provided by RGD
Official Full Name: N-myristoyltransferase 2provided by RGD
Primary source: RGD:1303175
See related: EnsemblRapid:ENSRNOG00000026248 AllianceGenome:RGD:1303175
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and protein localization to membrane. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 249.4), Adrenal (RPKM 227.6) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q12.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (79826999..79874088, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (74917833..74964788, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (78919235..78966013, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
Title: NMT2 alleviates depression-like behavior in a rat model of chronic unpredictable stress: An integrated proteomic and phosphoproteomic analysis.
NMT2 protein exhibited functional myristoyltransferase activity, but appeared to be 4-time less active than NMT1.
Title: Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH137920 (e-PCR)
- UniSTS:220007

RH138290 (e-PCR)
- UniSTS:220377

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glycylpeptide N-tetradecanoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycylpeptide N-tetradecanoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables glycylpeptide N-tetradecanoyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables peptidyl-lysine N6-myristoyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-glycine N-myristoylation	TAS Traceable Author Statement more info	PubMed
involved_in N-terminal protein myristoylation	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: glycylpeptide N-tetradecanoyltransferase 2

NP_001399348.1

EC 2.3.1.97

NP_997473.2

EC 2.3.1.97

XP_008770076.1

EC 2.3.1.97

XP_017455983.1

EC 2.3.1.97

XP_038951470.1

EC 2.3.1.97

XP_063132313.1

EC 2.3.1.97

XP_063132314.1

EC 2.3.1.97

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412419.1 → NP_001399348.1 glycylpeptide N-tetradecanoyltransferase 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6A8X5, F1M110

Related

ENSRNOP00000035716.6, ENSRNOT00000030228.7
NM_207590.2 → NP_997473.2 glycylpeptide N-tetradecanoyltransferase 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6JM25, Q700Q7

Related

ENSRNOP00000078750.2, ENSRNOT00000112511.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

79826999..79874088 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276243.1 → XP_063132313.1 glycylpeptide N-tetradecanoyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A8X5
XM_017600494.3 → XP_017455983.1 glycylpeptide N-tetradecanoyltransferase 2 isoform X4

UniProtKB/TrEMBL

A0A8I6A8X5
XM_039095542.2 → XP_038951470.1 glycylpeptide N-tetradecanoyltransferase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6A8X5

Conserved Domains (1) summary

COG5092
Location:125 → 492

NMT1; N-myristoyl transferase [Lipid metabolism]
XM_063276244.1 → XP_063132314.1 glycylpeptide N-tetradecanoyltransferase 2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZLL5, A0A8I5ZWZ4

Related

ENSRNOP00000083953.1, ENSRNOT00000119939.2
XM_008771854.4 → XP_008770076.1 glycylpeptide N-tetradecanoyltransferase 2 isoform X2

UniProtKB/TrEMBL

A0A8I6A8X5, A0A8I6A9A8

Related

ENSRNOP00000090038.1, ENSRNOT00000099682.2

Conserved Domains (2) summary

pfam01233
Location:144 → 298

NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain

pfam02799
Location:314 → 489

NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain