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    Ptgr2 prostaglandin reductase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptgr2provided by RGD
    Official Full Name
    prostaglandin reductase 2provided by RGD
    Primary source
    RGD:1310518
    See related
    EnsemblRapid:ENSRNOG00000038166 AllianceGenome:RGD:1310518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zadh1
    Summary
    Predicted to enable 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be located in cytoplasm. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 410.0), Muscle (RPKM 213.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptgr2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109662469..109694232)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103931367..103963113)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107999832..108031645)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103573 Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene uncharacterized LOC134479232 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6 monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2. Wu YH, et al. Structure, 2008 Nov 12. PMID 19000823
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC108784

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin reductase 2
    Names
    15-oxoprostaglandin 13-reductase
    PRG-2
    zinc binding alcohol dehydrogenase, domain containing 1
    zinc-binding alcohol dehydrogenase domain-containing protein 1
    NP_001015009.1
    NP_001386355.1
    NP_001386362.1
    XP_006240389.1
    XP_006240391.1
    XP_038967954.1
    XP_063117803.1
    XP_063117804.1
    XP_063117805.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015009.2 → NP_001015009.1  prostaglandin reductase 2 isoform 2

      See identical proteins and their annotated locations for NP_001015009.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5BK81
      Related
      ENSRNOP00000054903.2, ENSRNOT00000058095.5
      Conserved Domains (2) summary
      COG2130
      Location:4 → 277
      CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl16912
      Location:1 → 275
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. NM_001399426.1 → NP_001386355.1  prostaglandin reductase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5BK81
      UniProtKB/TrEMBL
      A0A8L2QSN3, A6JDT8
      Related
      ENSRNOP00000103460.1, ENSRNOT00000122406.1
      Conserved Domains (1) summary
      cd08293
      Location:1 → 345
      PTGR2; Prostaglandin reductase

    3. NM_001399433.1 → NP_001386362.1  prostaglandin reductase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6G545, A0A8L2QSN3
      Related
      ENSRNOP00000080851.1, ENSRNOT00000118264.2

    RNA

    1. NR_174185.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    2. NR_174186.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109662469..109694232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240327.4 → XP_006240389.1  prostaglandin reductase 2 isoform X1

      See identical proteins and their annotated locations for XP_006240389.1

      UniProtKB/Swiss-Prot
      Q5BK81
      UniProtKB/TrEMBL
      A0A8L2QSN3, A6JDT8
      Conserved Domains (1) summary
      cd08293
      Location:1 → 345
      PTGR2; Prostaglandin reductase

    2. XM_063261735.1 → XP_063117805.1  prostaglandin reductase 2 isoform X3

    3. XM_039112026.2 → XP_038967954.1  prostaglandin reductase 2 isoform X4

      UniProtKB/TrEMBL
      A6JDU4
      Conserved Domains (1) summary
      cl16912
      Location:1 → 175
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    4. XM_063261733.1 → XP_063117803.1  prostaglandin reductase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5BK81
      UniProtKB/TrEMBL
      A0A8L2QSN3, A6JDT8
      Related
      ENSRNOP00000055851.4, ENSRNOT00000059073.6

    5. XM_063261734.1 → XP_063117804.1  prostaglandin reductase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5BK81
      UniProtKB/TrEMBL
      A0A8L2QSN3, A6JDT8

    6. XM_006240329.5 → XP_006240391.1  prostaglandin reductase 2 isoform X2

      UniProtKB/TrEMBL
      A6JDU5
      Conserved Domains (1) summary
      cl16912
      Location:1 → 290
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK81.2 GenPept UniProtKB/Swiss-Prot:Q5BK81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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