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    Stil STIL, centriolar assembly protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stilprovided by RGD
    Official Full Name
    STIL, centriolar assembly proteinprovided by RGD
    Primary source
    RGD:1304972
    See related
    EnsemblRapid:ENSRNOG00000057760 AllianceGenome:RGD:1304972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sil
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of cell cycle process; and protein localization to centrosome. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic organ development; and non-motile cilium assembly. Predicted to be located in cytoplasm; microtubule organizing center; and nucleoplasm. Predicted to be part of procentriole replication complex. Predicted to be active in microtubule organizing center. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Orthologous to human STIL (STIL centriolar assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 67.6), Spleen (RPKM 49.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stil in Genome Data Viewer
    Location:
    5q35
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (133757598..133810493)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (128520837..128573732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (133819302..133851362)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene forkhead box E3 Neighboring gene cytidine/uridine monophosphate kinase 1 Neighboring gene TAL bHLH transcription factor 1, erythroid differentiation factor Neighboring gene uncharacterized LOC120102952 Neighboring gene PDZK1 interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons. Sun L, et al. Biochem Biophys Res Commun, 2014 Jul 11. PMID 24853807
    2. STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. Arquint C, et al. Elife, 2015 Jul 18. PMID 26188084, Free PMC Article
    3. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. Shiratsuchi G, et al. EMBO J, 2015 Jan 2. PMID 25385835, Free PMC Article
    4. Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. Campaner S, et al. Mol Cell Biol, 2005 Aug. PMID 16024801, Free PMC Article
    5. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. Tang CJ, et al. EMBO J, 2011 Oct 21. PMID 22020124, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results provide direct evidence for the involvement of Stil in dopaminergic cell proliferation
      Title: Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within floor plate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule organizing center organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within notochord development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SCL-interrupting locus protein
    Names
    Scl/Tal1 interrupting locus
    Tal1 interrupting locus

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399206.1 → NP_001386135.1  SCL-interrupting locus protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2KB96
      Conserved Domains (1) summary
      pfam15253
      Location:22 → 426
      STIL_N; SCL-interrupting locus protein N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      133757598..133810493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287731.1 → XP_063143801.1  SCL-interrupting locus protein isoform X4

    2. XM_039111180.2 → XP_038967108.1  SCL-interrupting locus protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB96
      Conserved Domains (1) summary
      pfam15253
      Location:22 → 426
      STIL_N; SCL-interrupting locus protein N-terminus

    3. XM_039111182.2 → XP_038967110.1  SCL-interrupting locus protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2KB96
      Related
      ENSRNOP00000075706.3, ENSRNOT00000081075.3
      Conserved Domains (1) summary
      pfam15253
      Location:17 → 402
      STIL_N; SCL-interrupting locus protein N-terminus

    4. XM_039111181.2 → XP_038967109.1  SCL-interrupting locus protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB96
      Conserved Domains (1) summary
      pfam15253
      Location:13 → 417
      STIL_N; SCL-interrupting locus protein N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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