Brinp2 BMP/retinoic acid inducible neural specific 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brinp2provided by RGD
Official Full Name: BMP/retinoic acid inducible neural specific 2provided by RGD
Primary source: RGD:708419
See related: EnsemblRapid:ENSRNOG00000005592 AllianceGenome:RGD:708419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam5b
Summary: Involved in negative regulation of cell cycle and nervous system development. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 124.9) and Testes (RPKM 18.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (72964498..73065312, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (70431006..70532766, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (75948679..76049363, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe BRINP1, 2, and 3 genes, which have distinct regulatory mechanisms of expression within the nervous system and which suppress the cell cycle progression in nonneuronal cells.
Title: Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.

Submit: New GeneRIF Correction

General gene information

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Markers

AU046789 (e-PCR)
- UniSTS:111132

RH143402 (e-PCR)
- UniSTS:232649

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BMP/retinoic acid-inducible neural-specific protein 2

Names: bone morphogenetic protein/retinoic acid inducible neural-specific 2; bone morphogenic protein/retinoic acid inducible neural-specific 2; family with sequence similarity 5, member B; protein FAM5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173115.2 → NP_775138.1 BMP/retinoic acid-inducible neural-specific protein 2 precursor

See identical proteins and their annotated locations for NP_775138.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q8K1M8

UniProtKB/TrEMBL

A6ID37, F1MA15

Related

ENSRNOP00000007455.8, ENSRNOT00000007455.9

Conserved Domains (2) summary

smart00457
Location:90 → 281

MACPF; membrane-attack complex / perforin

pfam19052
Location:336 → 783

BRINP; BMP/retinoic acid-inducible neural-specific protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

72964498..73065312 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090413.2 → XP_038946341.1 BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8K1M8

UniProtKB/TrEMBL

A6ID37, F1MA15

Conserved Domains (2) summary

smart00457
Location:90 → 281

MACPF; membrane-attack complex / perforin

pfam19052
Location:336 → 783

BRINP; BMP/retinoic acid-inducible neural-specific protein
XM_039090412.2 → XP_038946340.1 BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8K1M8

UniProtKB/TrEMBL

A6ID37, F1MA15

Conserved Domains (2) summary

smart00457
Location:90 → 281

MACPF; membrane-attack complex / perforin

pfam19052
Location:336 → 783

BRINP; BMP/retinoic acid-inducible neural-specific protein
XM_039090411.2 → XP_038946339.1 BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8K1M8

UniProtKB/TrEMBL

A6ID37, F1MA15

Conserved Domains (2) summary

smart00457
Location:90 → 281

MACPF; membrane-attack complex / perforin

pfam19052
Location:336 → 783

BRINP; BMP/retinoic acid-inducible neural-specific protein
XM_063272059.1 → XP_063128129.1 BMP/retinoic acid-inducible neural-specific protein 2 isoform X2