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    Cilp2 cartilage intermediate layer protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cilp2provided by RGD
    Official Full Name
    cartilage intermediate layer protein 2provided by RGD
    Primary source
    RGD:1311157
    See related
    EnsemblRapid:ENSRNOG00000020622 AllianceGenome:RGD:1311157
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be active in extracellular space. Orthologous to human CILP2 (cartilage intermediate layer protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 97.4), Muscle (RPKM 81.3) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cilp2 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19573821..19581100)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19539755..19547191)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21288782..21295869)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene PBX homeobox 4 Neighboring gene lysophosphatidic acid receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. One of two chondrocyte-expressed isoforms of cartilage intermediate-layer protein functions as an insulin-like growth factor 1 antagonist. Johnson K, et al. Arthritis Rheum, 2003 May. PMID 12746903
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables alkaline phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables dinucleotide phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cartilage intermediate layer protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107307.1 → NP_001100777.1  cartilage intermediate layer protein 2 precursor

      See identical proteins and their annotated locations for NP_001100777.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A6KAA7, D3ZE05
      Related
      ENSRNOP00000027990.5, ENSRNOT00000027990.7
      Conserved Domains (6) summary
      smart00408
      Location:333 → 393
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:168 → 207
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:325 → 404
      IG_like; Immunoglobulin like
      pfam13330
      Location:58 → 143
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      pfam13620
      Location:239 → 313
      CarboxypepD_reg; Carboxypeptidase regulatory-like domain
      pfam13715
      Location:502 → 553
      CarbopepD_reg_2; CarboxypepD_reg-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19573821..19581100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252902.5 → XP_006252964.1  cartilage intermediate layer protein 2 isoform X1

      Conserved Domains (6) summary
      smart00408
      Location:307 → 367
      IGc2; Immunoglobulin C-2 Type
      smart00209
      Location:158 → 197
      TSP1; Thrombospondin type 1 repeats
      smart00410
      Location:299 → 378
      IG_like; Immunoglobulin like
      pfam13330
      Location:58 → 143
      Mucin2_WxxW; Mucin-2 protein WxxW repeating region
      pfam13620
      Location:213 → 287
      CarboxypepD_reg; Carboxypeptidase regulatory-like domain
      pfam13715
      Location:476 → 527
      CarbopepD_reg_2; CarboxypepD_reg-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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