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    Ippk inositol-pentakisphosphate 2-kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ippkprovided by RGD
    Official Full Name
    inositol-pentakisphosphate 2-kinaseprovided by RGD
    Primary source
    RGD:1311271
    See related
    EnsemblRapid:ENSRNOG00000015631 AllianceGenome:RGD:1311271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rIpk1; C9orf12; RGD1311271
    Summary
    Enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 51.8), Brain (RPKM 49.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ippk in Genome Data Viewer
    Location:
    17p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15396691..15441648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15190191..15235203, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15604148..15643312, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene extracellular matrix protein 2 Neighboring gene uncharacterized LOC134482692 Neighboring gene ribosomal protein S12 like 8 Neighboring gene BICD cargo adaptor 2 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene uncharacterized LOC134482823

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase. Verbsky JW, et al. J Biol Chem, 2002 Aug 30. PMID 12084730
    2. A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells. Fujii M, et al. J Biol Chem, 2005 Jan 14. PMID 15528195
    3. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. Brehm MA, et al. J Cell Sci, 2013 Jan 15. PMID 23203802, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inositol-pentakisphosphate 2-kinase
    Names
    1,3,4,5,6-pentakisphosphate 2-kinase
    inositol polyphosphate kinase 1
    inositol-1,3,4,5,6-pentakisphosphate 2-kinase
    ins(1,3,4,5,6)P5 2-kinase
    insP5 2-kinase
    NP_001008556.2
    XP_008769757.1
    XP_038951584.1
    XP_038951585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008556.2 → NP_001008556.2  inositol-pentakisphosphate 2-kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q5PXE9
      UniProtKB/TrEMBL
      A6J6W4
      Related
      ENSRNOP00000021022.3, ENSRNOT00000021022.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15396691..15441648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095656.2 → XP_038951584.1  inositol-pentakisphosphate 2-kinase isoform X2

      UniProtKB/TrEMBL
      G3V7Z5
      Conserved Domains (1) summary
      pfam06090
      Location:13 → 389
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    2. XM_008771535.4 → XP_008769757.1  inositol-pentakisphosphate 2-kinase isoform X1

      See identical proteins and their annotated locations for XP_008769757.1

      UniProtKB/Swiss-Prot
      Q5PXE9
      Conserved Domains (1) summary
      pfam06090
      Location:1 → 393
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    3. XM_039095657.2 → XP_038951585.1  inositol-pentakisphosphate 2-kinase isoform X3

      Conserved Domains (1) summary
      pfam06090
      Location:13 → 273
      Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

    RNA

    1. XR_010058860.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PXE9.1 GenPept UniProtKB/Swiss-Prot:Q5PXE9

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