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    Hgfac HGF activator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hgfacprovided by RGD
    Official Full Name
    HGF activatorprovided by RGD
    Primary source
    RGD:70909
    See related
    EnsemblRapid:ENSRNOG00000009572 AllianceGenome:RGD:70909
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and rough endoplasmic reticulum. Orthologous to human HGFAC (HGF activator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 776.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hgfac in Genome Data Viewer
    Location:
    14q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79932219..79938773, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75707588..75714182, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80966902..80973525, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein associated protein 1 Neighboring gene docking protein 7 Neighboring gene regulator of G-protein signaling 12 Neighboring gene ribosomal protein S17 like 4 Neighboring gene regulator of G-protein signaling 12 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exogenously administered HGF activator augments liver regeneration through the production of biologically active HGF. Kaibori M, et al. Biochem Biophys Res Commun, 2002 Jan 11. PMID 11779195
    2. Changes in gene expression during progression of ovarian carcinoma. Tapper J, et al. Cancer Genet Cytogenet, 2001 Jul 1. PMID 11454421
    3. Immunohistochemical localization of hepatocyte growth factor activator (HGFA) in developing mouse liver tissues. Heterogeneous distribution of HGFA protein. Iida I, et al. J Histochem Cytochem, 2003 Sep. PMID 12923239
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109000

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hepatocyte growth factor activator
    NP_445772.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053320.1 → NP_445772.1  hepatocyte growth factor activator precursor

      See identical proteins and their annotated locations for NP_445772.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089871
      UniProtKB/TrEMBL
      F7ELL4, Q5EBA7
      Related
      ENSRNOP00000013257.5, ENSRNOT00000013257.8
      Conserved Domains (7) summary
      smart00059
      Location:99 → 145
      FN2; Fibronectin type 2 domain
      smart00020
      Location:405 → 639
      Tryp_SPc; Trypsin-like serine protease
      cd00054
      Location:159 → 194
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00061
      Location:197 → 237
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00190
      Location:406 → 641
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:242 → 274
      EGF; EGF-like domain
      pfam00051
      Location:283 → 364
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79932219..79938773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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