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    Ly6h lymphocyte antigen 6 family member H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300025, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ly6hprovided by RGD
    Official Full Name
    lymphocyte antigen 6 family member Hprovided by RGD
    Primary source
    RGD:1311896
    See related
    AllianceGenome:RGD:1311896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in synapse. Predicted to be active in plasma membrane. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 225.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ly6h in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109139527..109142108, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107258779..107261270, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116605556..116608072, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Ly6-C antigen like 1 Neighboring gene lymphocyte antigen 6 complex, locus A-like Neighboring gene lymphocyte antigen 6 family member L Neighboring gene glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 Neighboring gene zinc finger protein 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6H
    Names
    lymphocyte antigen 6 complex, locus H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134839.1 → NP_001128311.1  lymphocyte antigen 6H precursor

      See identical proteins and their annotated locations for NP_001128311.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HS09
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109139527..109142108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263270.1 → XP_063119340.1  lymphocyte antigen 6H isoform X1

      UniProtKB/TrEMBL
      A0A096MJ69, B5DFM3

    2. XM_006241783.5 → XP_006241845.1  lymphocyte antigen 6H isoform X2

      See identical proteins and their annotated locations for XP_006241845.1

      UniProtKB/TrEMBL
      A6HS09
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    3. XM_039078805.2 → XP_038934733.1  lymphocyte antigen 6H isoform X2

      UniProtKB/TrEMBL
      A6HS09
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    4. XM_039078804.2 → XP_038934732.1  lymphocyte antigen 6H isoform X2

      UniProtKB/TrEMBL
      A6HS09
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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