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    Psmd11 proteasome 26S subunit, non-ATPase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303353, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmd11provided by RGD
    Official Full Name
    proteasome 26S subunit, non-ATPase 11provided by RGD
    Primary source
    RGD:1306450
    See related
    EnsemblRapid:ENSRNOG00000005538 AllianceGenome:RGD:1306450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 190.0), Liver (RPKM 173.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmd11 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65923669..65977523)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (65433853..65479774)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67810655..67857562)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 17 open reading frame 75 Neighboring gene microRNA 632 Neighboring gene zinc finger protein 207 Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1 like Neighboring gene cyclin-dependent kinase 5 regulatory subunit 1 Neighboring gene myosin ID Neighboring gene uncharacterized LOC134480833

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Vilchez D, et al. Nature, 2012 Sep 13. PMID 22972301, Free PMC Article
    2. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Guo X, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 21949367, Free PMC Article
    3. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article
    4. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966
    5. Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. Wang X, et al. Biochemistry, 2007 Mar 20. PMID 17323924

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome accessory complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 11
    Names
    26S proteasome regulatory subunit RPN6
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394006.1 → NP_001380935.1  26S proteasome non-ATPase regulatory subunit 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LMZ8
      UniProtKB/TrEMBL
      B5DEP6
      Related
      ENSRNOP00000062146.2, ENSRNOT00000064285.4
      Conserved Domains (1) summary
      COG5159
      Location:17 → 421
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_172065.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65923669..65977523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269077.1 → XP_063125147.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWX1, A0A8I5ZWU3, A6HHB7

    2. XM_006246988.4 → XP_006247050.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_006247050.1

      UniProtKB/TrEMBL
      A0A0G2JWX1, A0A8I5ZWU3, A6HHB7
      Conserved Domains (2) summary
      COG5159
      Location:95 → 499
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:363 → 467
      PCI; PCI domain

    3. XM_006246987.4 → XP_006247049.1  26S proteasome non-ATPase regulatory subunit 11 isoform X1

      See identical proteins and their annotated locations for XP_006247049.1

      UniProtKB/TrEMBL
      A0A0G2JWX1, A0A8I5ZWU3, A6HHB7
      Related
      ENSRNOP00000070048.1, ENSRNOT00000079156.3
      Conserved Domains (2) summary
      COG5159
      Location:95 → 499
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:363 → 467
      PCI; PCI domain

    4. XM_063269078.1 → XP_063125148.1  26S proteasome non-ATPase regulatory subunit 11 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LMZ8.2 GenPept UniProtKB/Swiss-Prot:F1LMZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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