Dph2 diphthamide biosynthesis 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dph2provided by RGD
Official Full Name: diphthamide biosynthesis 2provided by RGD
Primary source: RGD:1304634
See related: AllianceGenome:RGD:1304634
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dph2l2
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to 2-(3-amino-3-carboxypropyl)histidine synthase activity. Predicted to be involved in protein histidyl modification to diphthamide. Predicted to be part of 2-(3-amino-3-carboxypropyl)histidine synthase complex. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 2. Orthologous to human DPH2 (diphthamide biosynthesis 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 52.4), Kidney (RPKM 48.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (136713868..136716828, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (131428434..131431394, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (136723398..136726358, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity	ISO Inferred from Sequence Orthology more info
contributes_to 2-(3-amino-3-carboxypropyl)histidine synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 4 iron, 4 sulfur cluster binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein histidyl modification to diphthamide	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	ISO Inferred from Sequence Orthology more info
involved_in protein histidyl modification to diphthamide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of 2-(3-amino-3-carboxypropyl)histidine synthase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Names: DPH2 homolog; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2; diphthamide biosynthesis protein 2; diphtheria toxin resistance protein 2; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 2

NP_001015007.1

EC 2.5.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015007.1 → NP_001015007.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

See identical proteins and their annotated locations for NP_001015007.1

Status: PROVISIONAL

Source sequence(s)

BC092656

UniProtKB/Swiss-Prot

Q568Y2

UniProtKB/TrEMBL

A6JZF3

Conserved Domains (1) summary

TIGR00322
Location:32 → 368

diphth2_R; diphthamide biosynthesis enzyme Dph1/Dph2 domain