Akt1s1 AKT1 substrate 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akt1s1provided by RGD
Official Full Name: AKT1 substrate 1provided by RGD
Primary source: RGD:1312049
See related: EnsemblRapid:ENSRNOG00000020289 AllianceGenome:RGD:1312049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PRAS40
Summary: Predicted to enable protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TORC1 signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Part of protein-containing complex. Orthologous to human AKT1S1 (AKT1 substrate 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 103.8), Heart (RPKM 95.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104469823..104476168)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (95333186..95339678)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100845443..100851961)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRAS40 appears to reduce brain injury following ischemic stroke by converting cell signaling from Akt to mTOR
Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
These data suggested that phosphorylation of PRAS40-Thr246 mediated abnormal lipid metabolism in kidney of diabetes and might be the potential target for treating lipogenesis of diabetic nephropathy.
Title: Phosphorylation of PRAS40-Thr246 involved in renal lipid accumulation of diabetes.
Taken together, these data demonstrate that IGF-1 stimulates the phosphorylation of PRAS40 at Thr246 in neuronal cells and the effect of IGF-1 is mediated, at least in part, by the PI3K/Akt signaling pathway.
Title: Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells.
Data identify high glucose-induced phosphorylation and inactivation of PRAS40 as a central node for mesangial cell hypertrophy in diabetic nephropathy.
Title: PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy.
effect of in vivo insulin action on phosphorylation of the PKB/Akt substrate 40
Title: Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.
overexpression of SOD1 in the Tg rats results in an increase in endogenous pPRAS40 and a decrease in motor neuron death through the PI3K/Akt pathway.
Title: Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proline-rich AKT1 substrate 1

Names: AKT1 substrate 1 (proline-rich); PKB/Akt substrate 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106259.3 → NP_001099729.2 proline-rich AKT1 substrate 1

See identical proteins and their annotated locations for NP_001099729.2

Status: VALIDATED

Source sequence(s)

BI276211, EV773331, FM032217, JAXUCZ010000001

UniProtKB/TrEMBL

A6JAT2, A6JAT3

Conserved Domains (1) summary

pfam15798
Location:128 → 252

PRAS; Proline-rich AKT1 substrate 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

104469823..104476168

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759335.4 → XP_008757557.1 proline-rich AKT1 substrate 1 isoform X5

Conserved Domains (1) summary

pfam15798
Location:42 → 166

PRAS; Proline-rich AKT1 substrate 1
XM_063283983.1 → XP_063140053.1 proline-rich AKT1 substrate 1 isoform X1

UniProtKB/TrEMBL

A6JAT2

Related

ENSRNOP00000101438.1, ENSRNOT00000167805.1
XM_006229004.5 → XP_006229066.1 proline-rich AKT1 substrate 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZRQ9, A6JAT2

Related

ENSRNOP00000079788.1, ENSRNOT00000114815.2

Conserved Domains (1) summary

pfam15798
Location:143 → 267

PRAS; Proline-rich AKT1 substrate 1
XM_006229005.5 → XP_006229067.1 proline-rich AKT1 substrate 1 isoform X3

UniProtKB/TrEMBL

A6JAT2

Conserved Domains (1) summary

pfam15798
Location:135 → 259

PRAS; Proline-rich AKT1 substrate 1
XM_039104846.2 → XP_038960774.1 proline-rich AKT1 substrate 1 isoform X4

UniProtKB/TrEMBL

A6JAT2, A6JAT3

Conserved Domains (1) summary

pfam15798
Location:128 → 252

PRAS; Proline-rich AKT1 substrate 1