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    Meis3 Meis homeobox 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Meis3provided by RGD
    Official Full Name
    Meis homeobox 3provided by RGD
    Primary source
    RGD:1308532
    See related
    EnsemblRapid:ENSRNOG00000021390 AllianceGenome:RGD:1308532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrg2
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including embryonic pattern specification; eye development; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in nucleus. Orthologous to several human genes including MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 32.1), Thymus (RPKM 23.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Meis3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (85986602..86000873)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76861267..76872691)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78065617..78079698)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kaptin (actin binding protein) Neighboring gene solute carrier family 8 member A2 Neighboring gene DExH-box helicase 34 Neighboring gene transmembrane protein 64-like Neighboring gene complement C5a receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Liu J, et al. Proc Natl Acad Sci U S A, 2010 Nov 23. PMID 21059917, Free PMC Article
    2. Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon. Shim S, et al. Mol Cell Biol, 2007 Mar. PMID 17178831, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Meis3
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog 3
    myeloid ecotropic viral integration site-related gene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108472.2 → NP_001101942.1  homeobox protein Meis3 isoform 2

      See identical proteins and their annotated locations for NP_001101942.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQ93, A6J899, D4A9U2
      Conserved Domains (2) summary
      pfam05920
      Location:283 → 322
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 182
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_001399601.1 → NP_001386530.1  homeobox protein Meis3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQ93, B1H242
      Related
      ENSRNOP00000063858.3, ENSRNOT00000068406.5
      Conserved Domains (2) summary
      pfam05920
      Location:335 → 373
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 234
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    3. NM_001399602.1 → NP_001386531.1  homeobox protein Meis3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AQ93

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      85986602..86000873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266350.1 → XP_063122420.1  homeobox protein Meis3 isoform X8

    2. XM_063266346.1 → XP_063122416.1  homeobox protein Meis3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQ93, B1H242

    3. XM_039081649.2 → XP_038937577.1  homeobox protein Meis3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ93
      Conserved Domains (2) summary
      pfam05920
      Location:348 → 387
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 234
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_063266349.1 → XP_063122419.1  homeobox protein Meis3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AQ93

    5. XM_063266345.1 → XP_063122415.1  homeobox protein Meis3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQ93

    6. XM_039081657.2 → XP_038937585.1  homeobox protein Meis3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ93
      Conserved Domains (2) summary
      pfam05920
      Location:343 → 382
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 234
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_063266348.1 → XP_063122418.1  homeobox protein Meis3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AQ93

    8. XM_006228351.5 → XP_006228413.1  homeobox protein Meis3 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AQ93
      Conserved Domains (2) summary
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    9. XM_039081664.2 → XP_038937592.1  homeobox protein Meis3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQ93
      Conserved Domains (2) summary
      pfam05920
      Location:297 → 336
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 183
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    10. XM_039081673.2 → XP_038937601.1  homeobox protein Meis3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AQ93
      Conserved Domains (2) summary
      pfam05920
      Location:280 → 319
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:99 → 166
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    11. XM_039081690.2 → XP_038937618.1  homeobox protein Meis3 isoform X9

      Conserved Domains (2) summary
      pfam05920
      Location:213 → 252
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:1 → 99
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    12. XM_039081693.2 → XP_038937621.1  homeobox protein Meis3 isoform X10

      Conserved Domains (2) summary
      pfam05920
      Location:162 → 201
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:1 → 48
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    13. XM_039081694.2 → XP_038937622.1  homeobox protein Meis3 isoform X11

      Conserved Domains (2) summary
      pfam05920
      Location:145 → 184
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:1 → 31
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein Strain
    Heading Accession and Version

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