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    Thsd4 thrombospondin type 1 domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315728, updated on 9-Dec-2024

    Summary

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    Symbol
    Thsd4provided by RGD
    Full Name
    thrombospondin type 1 domain containing 4provided by RGD
    Primary source
    RGD:1566296
    See related
    EnsemblRapid:ENSRNOG00000053753 AllianceGenome:RGD:1566296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566296; AABR07070307.1
    Summary
    Predicted to be involved in microfibril assembly. Predicted to act upstream of or within elastic fiber assembly. Predicted to be located in microfibril. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human THSD4 (thrombospondin type 1 domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 72.9), Kidney (RPKM 45.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thsd4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (69280397..69880144, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (60384636..60984419, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (64811940..65413498, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myosin IXA Neighboring gene uncharacterized LOC102546766 Neighboring gene nuclear receptor subfamily 2, group E, member 3 Neighboring gene uncharacterized LOC134480061 Neighboring gene uncharacterized LOC120094180 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene leucine rich repeat containing 49 Neighboring gene uncharacterized LOC108351719 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. Tsutsui K, et al. J Biol Chem, 2010 Feb 12. PMID 19940141, Free PMC Article
    2. SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Zanivan S, et al. Mol Cell Proteomics, 2013 Dec. PMID 23979707, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within elastic fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microfibril assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thrombospondin type 1 domain containing 4; thrombospondin type-1 domain-containing protein 4
    Names
    thrombospondin, type I, domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429247.1 → NP_001416176.1  thrombospondin type 1 domain containing 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AN95

    2. NM_001429249.1 → NP_001416178.1  thrombospondin type 1 domain containing 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6A1T6, A6J545

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      69280397..69880144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082429.2 → XP_038938357.1  thrombospondin type-1 domain-containing protein 4 isoform X1

      Related
      ENSRNOP00000094090.1, ENSRNOT00000081697.3
      Conserved Domains (4) summary
      PHA03247
      Location:34 → 213
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:411 → 527
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:974 → 1004
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:855 → 911
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_039082430.2 → XP_038938358.1  thrombospondin type-1 domain-containing protein 4 isoform X2

      Related
      ENSRNOP00000085220.1, ENSRNOT00000085526.3
      Conserved Domains (3) summary
      pfam05986
      Location:52 → 168
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:615 → 645
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:496 → 552
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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