Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp4a1provided by RGD
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:68945
See related: EnsemblRapid:ENSRNOG00000009597 AllianceGenome:RGD:68945
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp4a10; Cyp4a22; CYPIVA10
Summary: Enables alkane 1-monooxygenase activity and arachidonate monooxygenase activity. Involved in several processes, including fatty acid metabolic process; icosanoid biosynthetic process; and placenta development. Predicted to be located in extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Biomarker of autosomal recessive polycystic kidney disease and hypertension. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 370.4) and Kidney (RPKM 215.5) See more
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Genomic context

Location:: 5q35

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134360096..134374233)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129123323..129137464)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134492734..134507158)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicated that AngII chronically increased the CYP4A isoform expression in the rat kidney. The AngII-induced CYP4A isoform expression was mediated by AT1-R.
Title: Angiotensin II upregulates CYP4A isoform expression in the rat kidney through angiotensin II type 1 receptor.
The CYP4A pathway plays a role in vascular dysfunction in SS rats and there appears to be a direct role of reduced NO availability due to salt-induced oxidant stress in upregulating CYP4A enzyme expression.
Title: Role of vascular reactive oxygen species in regulating cytochrome P450-4A enzyme expression in Dahl salt-sensitive rats.
rosuvastatin downregulates CYP4A1 in spontaneously hypertensive rats
Title: Effects of rosuvastatin correlated with the down-regulation of CYP4A1 in spontaneously hypertensive rats.
In CYP4A1 transgenic Dahl salt-sensitive rat formation of 20-HETE in the cerebral vasculature was elevated rescuing impaired myogenic response/autoregulation of cerebrovascular blood flow.
Title: Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.
Salt sensitive rats have an up-regulation of the CYP4A/20-HETE pathway resulting in elevated reactive oxygen species and reduced NO bioavailability causing vascular dysfunction.
Title: Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats.
in the presence of testosterone, the Cyp4A/20-HETE system plays a key role in elevating the blood pressure secondary to insulin resistance.
Title: Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats.
NO differentially regulates the function of CYP4A1, -4A2, and -4A3 isoforms in the renal vasculature and the nephron.
Title: Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat.
CYP450-4A enzymes contribute to resting tone and to an enhanced response to elevated PO(2) in arterioles of Dahl-SS rats fed the high-salt diet.
Title: Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats.
CYP4A1 and CYP2C11 expression levels were lower in SHRSP/Izm than those in age-matched male spontaneously hypertensive rats
Title: The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats.
Cyp4a1 is upregulated after treatment with Wy-14643 in rat liver
Title: Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

D5MGH27 (e-PCR)
- UniSTS:122060

RH129146 (e-PCR)
- UniSTS:212454

D5Rjr1 (e-PCR)
- UniSTS:239612

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 16-hydroxypalmitate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables arachidonate monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonate monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate monooxygenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables arachidonate omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
NOT involved_in omega-hydroxylase P450 pathway	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 4A10

Names: cytochrome P450, 4A1; cytochrome P450, 4a10; cytochrome P450, IVA1; cytochrome P450, family 4, subfamily A, polypeptide 22; cytochrome P450, family 4, subfamily a, polypeptide 10; cytochrome P450-LA-omega 1; cytochrome P452; lauric acid omega-hydroxylase; long-chain fatty acid omega-monooxygenase

NP_787031.1

EC 1.14.14.80

XP_006238774.1

EC 1.14.14.80

XP_063144390.1

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.