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    Fancc FA complementation group C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24361, updated on 9-Dec-2024

    Summary

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    Symbol
    Fanccprovided by RGD
    Full Name
    FA complementation group Cprovided by RGD
    Primary source
    RGD:2593
    See related
    EnsemblRapid:ENSRNOG00000016889 AllianceGenome:RGD:2593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Facc
    Summary
    Predicted to be involved in cellular response to oxidative stress and nucleotide-excision repair. Predicted to act upstream of or within several processes, including brain morphogenesis; neuronal stem cell population maintenance; and removal of superoxide radicals. Located in chromatin. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); acute myeloid leukemia; aspirin-induced respiratory disease; pancreatic cancer; and pancytopenia. Orthologous to human FANCC (FA complementation group C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 46.8), Thymus (RPKM 44.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fancc in Genome Data Viewer
    Location:
    17p14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (1686374..1818672)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (1680660..1822610)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (826512..955703, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene patched 1 Neighboring gene uncharacterized LOC134482656 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene microRNA 3074 Neighboring gene microRNA 24-1 Neighboring gene microRNA 27b Neighboring gene microRNA 23b Neighboring gene aminopeptidase O

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Carreau M, et al. Blood, 1998 Apr 15. PMID 9531583
    2. Phenotypic correction of Fanconi anemia group C knockout mice. Gush KA, et al. Blood, 2000 Jan 15. PMID 10627482
    3. Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia. Barber LM, et al. Br J Haematol, 2003 Apr. PMID 12670332
    4. A Leu554-to-Pro substitution completely abolishes the functional complementing activity of the Fanconi anemia (FACC) protein. Gavish H, et al. Hum Mol Genet, 1993 Feb. PMID 8499901
    5. Fanconi anemia links reactive oxygen species to insulin resistance and obesity. Li J, et al. Antioxid Redox Signal, 2012 Oct 15. PMID 22482891, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in brain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within germ cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myeloid cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myeloid cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Fanconi anaemia nuclear complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Fanconi anaemia nuclear complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi anemia group C protein homolog
    Names
    Fanconi anemia, complementation group C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012557.2 → NP_036689.2  Fanconi anemia group C protein homolog

      See identical proteins and their annotated locations for NP_036689.2

      Status: PROVISIONAL

      Source sequence(s)
      BC168147
      UniProtKB/Swiss-Prot
      O35870
      UniProtKB/TrEMBL
      B4F762
      Related
      ENSRNOP00000101125.1, ENSRNOT00000164718.1
      Conserved Domains (1) summary
      pfam02106
      Location:10 → 554
      Fanconi_C; Fanconi anaemia group C protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      1686374..1818672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276053.1 → XP_063132123.1  Fanconi anemia group C protein homolog isoform X5

    2. XM_006253489.5 → XP_006253551.1  Fanconi anemia group C protein homolog isoform X2

      See identical proteins and their annotated locations for XP_006253551.1

      UniProtKB/Swiss-Prot
      O35870
      UniProtKB/TrEMBL
      B4F762
      Related
      ENSRNOP00000022884.6, ENSRNOT00000022884.8
      Conserved Domains (1) summary
      pfam02106
      Location:10 → 554
      Fanconi_C; Fanconi anaemia group C protein

    3. XM_063276051.1 → XP_063132121.1  Fanconi anemia group C protein homolog isoform X2

      UniProtKB/Swiss-Prot
      O35870
      UniProtKB/TrEMBL
      B4F762

    4. XM_063276050.1 → XP_063132120.1  Fanconi anemia group C protein homolog isoform X2

      UniProtKB/Swiss-Prot
      O35870
      UniProtKB/TrEMBL
      B4F762

    5. XM_063276049.1 → XP_063132119.1  Fanconi anemia group C protein homolog isoform X1

      UniProtKB/Swiss-Prot
      O35870

    6. XM_063276052.1 → XP_063132122.1  Fanconi anemia group C protein homolog isoform X4

    7. XM_006253491.5 → XP_006253553.1  Fanconi anemia group C protein homolog isoform X3

      UniProtKB/Swiss-Prot
      O35870
      Conserved Domains (1) summary
      pfam02106
      Location:24 → 463
      Fanconi_C; Fanconi anaemia group C protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35870.1 GenPept UniProtKB/Swiss-Prot:O35870

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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