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    Pla2g2c phospholipase A2, group IIC [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pla2g2cprovided by RGD
    Official Full Name
    phospholipase A2, group IICprovided by RGD
    Primary source
    RGD:3340
    See related
    EnsemblRapid:ENSRNOG00000016647 AllianceGenome:RGD:3340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium-dependent phospholipase A2 activity. Predicted to be involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region and membrane. Orthologous to human PLA2G2C (phospholipase A2 group IIC). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 21.9), Brain (RPKM 6.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2g2c in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156241142..156262368)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150959365..150981388)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157163672..157187654)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351047 Neighboring gene von Willebrand factor A domain containing 5B1 Neighboring gene uncharacterized LOC108351048 Neighboring gene UBX domain protein 10 Neighboring gene phospholipase A2, group IIF Neighboring gene phospholipase A2, group IID

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of novel rat and mouse low molecular weight Ca(2+)-dependent phospholipase A2s containing 16 cysteines. Chen J, et al. J Biol Chem, 1994 Sep 16. PMID 8083202
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-independent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    group IIC secretory phospholipase A2
    Names
    14 kDa phospholipase A2
    GIIC sPLA2
    PLA2-8
    phosphatidylcholine 2-acylhydrolase 2C
    phosphatidylcholine 2-acylhydrolase GIIC
    phospholipase A2, group 2C
    sPLA2-IIC
    NP_062075.1
    XP_006239204.1
    XP_006239205.1
    XP_038965296.1
    XP_038965297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434535.1 → NP_001421464.1  group IIC secretory phospholipase A2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P39878
      UniProtKB/TrEMBL
      A0A0G2K3F5, Q4V8L7

    2. NM_001434536.1 → NP_001421465.1  group IIC secretory phospholipase A2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P39878
      UniProtKB/TrEMBL
      A0A0G2K3F5, Q4V8L7

    3. NM_001434537.1 → NP_001421466.1  group IIC secretory phospholipase A2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P39878
      UniProtKB/TrEMBL
      A0A0G2K3F5, Q4V8L7

    4. NM_019202.3 → NP_062075.1  group IIC secretory phospholipase A2 precursor

      See identical proteins and their annotated locations for NP_062075.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P39878
      UniProtKB/TrEMBL
      A0A0G2K3F5, Q4V8L7
      Conserved Domains (1) summary
      smart00085
      Location:29 → 148
      PA2c; Phospholipase A2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156241142..156262368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239143.5 → XP_006239205.1  group IIC secretory phospholipase A2 isoform X1

      See identical proteins and their annotated locations for XP_006239205.1

      UniProtKB/Swiss-Prot
      P39878
      UniProtKB/TrEMBL
      A0A0G2K3F5, Q4V8L7
      Related
      ENSRNOP00000072615.1, ENSRNOT00000087072.3
      Conserved Domains (1) summary
      smart00085
      Location:29 → 148
      PA2c; Phospholipase A2

    2. XM_039109369.2 → XP_038965297.1  group IIC secretory phospholipase A2 isoform X1

      Conserved Domains (1) summary
      smart00085
      Location:29 → 148
      PA2c; Phospholipase A2

    3. XM_006239142.5 → XP_006239204.1  group IIC secretory phospholipase A2 isoform X1

      Conserved Domains (1) summary
      smart00085
      Location:29 → 148
      PA2c; Phospholipase A2

    4. XM_039109368.2 → XP_038965296.1  group IIC secretory phospholipase A2 isoform X1

      Conserved Domains (1) summary
      smart00085
      Location:29 → 148
      PA2c; Phospholipase A2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39878.2 GenPept UniProtKB/Swiss-Prot:P39878

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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