Cd93 CD93 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd93provided by RGD
Official Full Name: CD93 moleculeprovided by RGD
Primary source: RGD:621251
See related: EnsemblRapid:ENSRNOG00000024799 AllianceGenome:RGD:621251
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ly68; C1qRp; C1qr1
Summary: Predicted to enable complement component C1q complex binding activity and signaling receptor activity. Predicted to be involved in angiogenesis and cell-cell adhesion. Predicted to be located in cell surface; cytoplasmic vesicle; and plasma membrane. Orthologous to human CD93 (CD93 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 632.7), Heart (RPKM 284.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (156345019..156351537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (135891859..135898378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (142778798..142783774, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synergistic regulation of microglia differentiation by CD93 and integrin beta1 in the rat pneumococcal meningitis model.
Title: Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model.
Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
Title: Crosstalk between CD93, C1q and GIPC in the Regulation of Pneumococcal Meningitis Inflammation.
These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages
Title: Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.
The authors observed that binding of gC1qR to the full-length receptor modifies the intrinsic tryptophan fluorescence binding curves of V2 to an antagonist.
Title: Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.

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General gene information

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Markers

Ly68 (e-PCR), detects polymorphism
- UniSTS:226141

AW555904 (e-PCR)
- UniSTS:185503

RH137518 (e-PCR)
- UniSTS:219606

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C1q receptor

Names: C1q/MBL/SPA receptor; C1qR(p); CD93 antigen; cell surface antigen AA4; complement component 1 q subcomponent receptor 1; lymphocyte antigen 68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053383.4 → NP_445835.2 complement component C1q receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9ET61, Q9JIZ6

UniProtKB/TrEMBL

A6K7C0

Related

ENSRNOP00000089608.1, ENSRNOT00000076493.3

Conserved Domains (5) summary

smart00179
Location:424 → 462

EGF_CA; Calcium-binding EGF-like domain

pfam00008
Location:303 → 331

EGF; EGF-like domain

pfam12662
Location:323 → 345

cEGF; Complement Clr-like EGF-like

pfam14670
Location:261 → 297

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl02432
Location:30 → 183

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain