Esm1 endothelial cell-specific molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Esm1provided by RGD
Official Full Name: endothelial cell-specific molecule 1provided by RGD
Primary source: RGD:71013
See related: EnsemblRapid:ENSRNOG00000010797 AllianceGenome:RGD:71013
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pg25
Summary: Predicted to enable hepatocyte growth factor receptor binding activity and integrin binding activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of hepatocyte growth factor receptor signaling pathway; and sprouting angiogenesis. Predicted to be located in extracellular region. Orthologous to human ESM1 (endothelial cell specific molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 114.0), Lung (RPKM 93.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (46609253..46617991)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (44876067..44884805)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (45104392..45113130)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peripheral blood ESM-1 mRNA and ESM-1 protein expression in kidney grafts can reflect the severity of endothelial cell impairment
Title: Detection and mechanism of action of ESM-1 in rat kidney transplantation under various immune states.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hepatocyte growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hepatocyte growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatocyte growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endothelial cell-specific molecule 1

Names: ESM-1 secretory protein; pineal specific PG25 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022604.2 → NP_072126.1 endothelial cell-specific molecule 1 precursor

See identical proteins and their annotated locations for NP_072126.1

Status: PROVISIONAL

Source sequence(s)

BC070888

UniProtKB/Swiss-Prot

P97682

UniProtKB/TrEMBL

A6I5R2

Related

ENSRNOP00000014559.3, ENSRNOT00000014559.7

Conserved Domains (1) summary

pfam00219
Location:28 → 83

IGFBP; Insulin-like growth factor binding protein