Casp2 caspase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Casp2provided by RGD
Official Full Name: caspase 2provided by RGD
Primary source: RGD:69274
See related: EnsemblRapid:ENSRNOG00000016707 AllianceGenome:RGD:69274
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; identical protein binding activity; and protein domain specific binding activity. Involved in luteolysis; neural retina development; and positive regulation of neuron apoptotic process. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 234.6), Spleen (RPKM 136.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (72116265..72134023)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (71149632..71167388)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (71652358..71670228)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2.
Title: MiR-1247-3p protects rat cardiomyocytes against hypoxia/reoxygenation-induced injury via targeting BCL2L11 and caspase-2.
Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
Title: Involvement of Upregulated P53-Induced Death Domain Protein in Retinal Ganglion Cells Apoptosis After Optic Nerve Crush.
Caspase-2 mediates death in a proportion of retinal ganglion cell (RGC) but not photoreceptors at the site of blunt ocular trauma.
Title: Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury.
SiRNA-mediated downregulation of CASP2 protected 50% of DRGN from apoptosis after serum withdrawal.
Title: Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from apoptosis after serum withdrawal.
Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Title: Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.
Retinal ganglion cell apoptosis induced by optic nerve injury involves activation of caspase-2, and synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in diseases involving RGC loss
Title: Ocular neuroprotection by siRNA targeting caspase-2.
ras-induced down-regulation of caspase-2 represents a novel mechanism by which oncogenic Ras protects malignant intestinal epithelial cells from anoikis
Title: Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.
Blockade of caspase 2 activation prevents heat-induced germ cell apoptosis in rats by suppressing the MAPK14- and NO-mediated intrinsic pathway signaling.
Title: Role of caspase 2 in apoptotic signaling in primate and murine germ cells.
DMNQ-induced oxidative stress causes p53 accumulation and consequently caspase-2 activation, which in turn initiates apoptotic cell death via the mitochondria-mediated caspase-dependent pathway in neural stem cells.
Title: Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis.
Data suggest that caspase 2-mediated programmed cell death participates in the seizure-induced degenerative process in experimental and human TLE.
Title: Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

MARC_16655-16656:1017778016:1 (e-PCR)
- UniSTS:268065

RH127476 (e-PCR)
- UniSTS:210786

Casp2 (e-PCR), detects polymorphism
- UniSTS:265593

Casp2 (e-PCR), detects polymorphism
- UniSTS:259199

RH140969 (e-PCR)
- UniSTS:222970

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectopic germ cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death	TAS Traceable Author Statement more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caspase-2

Names: CASP-2; ICH-1 protease; protease ICH-1

NP_071967.2

EC 3.4.22.55

XP_038964246.1

EC 3.4.22.55

XP_063142731.1

EC 3.4.22.55

XP_063142732.1

EC 3.4.22.55

XP_063142733.1

EC 3.4.22.55

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022522.3 → NP_071967.2 caspase-2

See identical proteins and their annotated locations for NP_071967.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O35398, O55194, P55215, Q9WUI6

UniProtKB/TrEMBL

A6IF65

Related

ENSRNOP00000022672.2, ENSRNOT00000022672.8

Conserved Domains (2) summary

smart00115
Location:192 → 447

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

cd08332
Location:32 → 118

CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

72116265..72134023

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286661.1 → XP_063142731.1 caspase-2 isoform X1

UniProtKB/TrEMBL

A6IF66, D3ZLT0

Related

ENSRNOP00000096921.2, ENSRNOT00000112830.2
XM_039108318.2 → XP_038964246.1 caspase-2 isoform X2

Conserved Domains (2) summary

cl00042
Location:192 → 249

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:32 → 118

DD; Death Domain Superfamily of protein-protein interaction domains
XM_063286662.1 → XP_063142732.1 caspase-2 isoform X3
XM_063286663.1 → XP_063142733.1 caspase-2 isoform X4