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    TCH3 Calcium-binding EF hand family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818709, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TCH3
    Official Full Name
    Calcium-binding EF hand family protein
    Primary source
    TAIR:AT2G41100
    Locus tag
    AT2G41100
    See related
    Araport:AT2G41100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA CALMODULIN LIKE 4; ATCAL4; calmodulin-like 12; CALMODULIN-RELATED PROTEIN; CML12; T3K9.13; T3K9_13; TOUCH 3
    Summary
    encodes a calmodulin-like protein, with six potential calcium binding domains. Calcium binding shown by Ca(2+)-specific shift in electrophoretic mobility. Expression induced by touch and darkness. Expression may also be developmentally controlled. Expression in growing regions of roots, vascular tissue, root/shoot junctions, trichomes, branch points of the shoot, and regions of siliques and flowers.
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    Genomic context

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    See TCH3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (17137037..17139700)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Calcium-binding EF-hand family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene calmodulin 2 Neighboring gene DUF309 domain protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Touch-inducible genes for calmodulin and a calmodulin-related protein are located in tandem on a chromosome of Arabidopsis thaliana. Ito T, et al. Plant Cell Physiol, 1995 Oct. PMID 8564305
    2. Arabidopsis TCH3 encodes a novel Ca2+ binding protein and shows environmentally induced and tissue-specific regulation. Sistrunk ML, et al. Plant Cell, 1994 Nov. PMID 7827491, Free PMC Article
    3. PINOID-mediated signaling involves calcium-binding proteins. Benjamins R, et al. Plant Physiol, 2003 Jul. PMID 12857841, Free PMC Article
    4. ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance. Campe R, et al. New Phytol, 2016 Jan. PMID 26315018
    5. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036446.2
    NM_001202794.1
    NM_001336892.1
    NM_001336893.1
    NM_001336894.1
    NM_001336895.1
    NM_129675.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within thigmotropism IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Calcium-binding EF hand family protein
    NP_001189723.1
    • TOUCH 3 (TCH3); CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.3).
    NP_001318399.1
    • TOUCH 3 (TCH3); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to mechanical stimulus, response to temperature stimulus, thigmotropism, response to absence of light; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001318400.1
    • TOUCH 3 (TCH3); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to mechanical stimulus, response to temperature stimulus, thigmotropism, response to absence of light; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_181643.1
    • TOUCH 3 (TCH3); FUNCTIONS IN: calcium ion binding; INVOLVED IN: response to mechanical stimulus, response to temperature stimulus, thigmotropism, response to absence of light; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.3); Has 47548 Blast hits to 19426 proteins in 1680 species: Archae - 4; Bacteria - 353; Metazoa - 18604; Fungi - 12275; Plants - 9433; Viruses - 2; Other Eukaryotes - 6877 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17137037..17139700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336893.1 → NP_001318400.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EI63, F4IJ44

    2. NM_001336894.1 → NP_001324805.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B183, C0Z374

    3. NM_001336895.1 → NP_001324806.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EI63, F4IJ44

    4. NM_001202794.1 → NP_001189723.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25071, Q38972, Q39064, Q8H1A0
      UniProtKB/TrEMBL
      A0A5S9X614, A0A654F633, A0A7G2EI63
      Conserved Domains (1) summary
      PTZ00184
      Location:90 → 255
      PTZ00184; calmodulin; Provisional

    5. NM_001036446.2 → NP_001031523.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031523.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EI63, F4IJ44
      Conserved Domains (3) summary
      PTZ00184
      Location:55 → 220
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:156 → 218
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:14 → 91
      EF-hand_7; EF-hand domain pair

    6. NM_129675.5 → NP_181643.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25071, Q38972, Q39064, Q8H1A0
      UniProtKB/TrEMBL
      A0A5S9X614, A0A654F633, A0A7G2EI63
      Conserved Domains (1) summary
      PTZ00184
      Location:90 → 255
      PTZ00184; calmodulin; Provisional

    7. NM_001336892.1 → NP_001318399.1  Calcium-binding EF hand family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VN60, F4IJ45
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25071.3

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