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    HA1 H[+]-ATPase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816413, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HA1
    Official Full Name
    H[+]-ATPase 1
    Primary source
    TAIR:AT2G18960
    Locus tag
    AT2G18960
    See related
    Araport:AT2G18960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AHA1; F19F24.16; F19F24_16; H(+)-ATPase 1; OPEN STOMATA 2; OST2; PLASMA MEMBRANE PROTON ATPASE; PMA
    Summary
    Encodes a plasma membrane proton ATPase. Mutants have a reduced ability to close their stomata in response to drought and are affected in stomatal but not seed responsiveness to ABA.
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    Genomic context

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    See HA1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Sequence:
    Chromosome: 2; NC_003071.7 (8221514..8227622)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene homogentisate phytyltransferase 1 Neighboring gene transcription factor/transcription regulator Neighboring gene uncharacterized protein Neighboring gene Peroxidase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and sequence of cDNA encoding the plasma membrane proton pump (H+-ATPase) of Arabidopsis thaliana. Harper JF, et al. Proc Natl Acad Sci U S A, 1989 Feb. PMID 2521951, Free PMC Article
    2. GABA operates upstream of H+-ATPase and improves salinity tolerance in Arabidopsis by enabling cytosolic K+ retention and Na+ exclusion. Su N, et al. J Exp Bot, 2019 Nov 18. PMID 31420662, Free PMC Article
    3. The Plasma Membrane H+-ATPase AHA1 Plays a Major Role in Stomatal Opening in Response to Blue Light. Yamauchi S, et al. Plant Physiol, 2016 Aug. PMID 27261063, Free PMC Article
    4. Constitutive activation of a plasma membrane H(+)-ATPase prevents abscisic acid-mediated stomatal closure. Merlot S, et al. EMBO J, 2007 Jul 11. PMID 17557075, Free PMC Article
    5. A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions. Planes MD, et al. J Exp Bot, 2015 Feb. PMID 25371509, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SNARE SYP132 mediates divergent traffic of plasma membrane H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis.
      Title: SNARE SYP132 mediates divergent traffic of plasma membrane H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis.
    2. MPK6 Kinase Regulates Plasma Membrane H(+)-ATPase Activity in Cold Acclimation.
      Title: MPK6 Kinase Regulates Plasma Membrane H(+)-ATPase Activity in Cold Acclimation.
    3. Unusual Roles of Secretory SNARE SYP132 in Plasma Membrane H(+)-ATPase Traffic and Vegetative Plant Growth.
      Title: Unusual Roles of Secretory SNARE SYP132 in Plasma Membrane H(+)-ATPase Traffic and Vegetative Plant Growth.
    4. GABA operates upstream of H+-ATPase and improves salinity tolerance in Arabidopsis by enabling cytosolic K+ retention and Na+ exclusion.
      Title: GABA operates upstream of H+-ATPase and improves salinity tolerance in Arabidopsis by enabling cytosolic K+ retention and Na+ exclusion.
    5. AHA1 plays a major role in blue light-dependent stomatal opening in Arabidopsis.
      Title: The Plasma Membrane H+-ATPase AHA1 Plays a Major Role in Stomatal Opening in Response to Blue Light.
    6. RIN4 T21D/S160D/T166D phosphomimetic mutants exhibited enhanced disease susceptibility upon surface inoculation with P. syringae, wider stomatal apertures, and enhanced plasma membrane H(+)-ATPase activity.
      Title: Phosphorylation of the Plant Immune Regulator RPM1-INTERACTING PROTEIN4 Enhances Plant Plasma Membrane H⁺-ATPase Activity and Inhibits Flagellin-Triggered Immune Responses in Arabidopsis.
    7. Pseudomonas syringae type III effector protein AvrB induces stomatal opening and enhances bacterial virulence in a manner dependent on RIN4, which promotes stomatal opening by positively regulating the Arabidopsis plasma membrane H(+)-ATPase.
      Title: An Arabidopsis Plasma Membrane Proton ATPase Modulates JA Signaling and Is Exploited by the Pseudomonas syringae Effector Protein AvrB for Stomatal Invasion.
    8. ABA inhibited the root plasma-membrane H(+)-ATPase measured in vitro (ATP hydrolysis by isolated vesicles) and in vivo (H(+) efflux from seedling roots).
      Title: A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions.
    9. The major plasma membrane proton pumps in Arabidopsis, AHA1 and AHA2, interact directly in vitro and in planta with PSY1R, a receptor kinase of the plasma membrane that serves as a receptor for the peptide growth hormone PSY1.
      Title: Receptor kinase-mediated control of primary active proton pumping at the plasma membrane.
    10. A Munc13-like protein in Arabidopsis (PATROL1) mediates AHA1 translocation that is essential for stomatal responses.
      Title: A Munc13-like protein in Arabidopsis mediates H+-ATPase translocation that is essential for stomatal responses.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335617.1
    NM_127453.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables P-type proton-exporting transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type proton-exporting transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proton export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within proton transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal opening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    H[+]-ATPase 1
    NP_179486.1
    • H(+)-ATPase 1 (HA1); FUNCTIONS IN: protein binding, ATPase activity, hydrogen-exporting ATPase activity, phosphorylative mechanism; INVOLVED IN: response to water deprivation, proton transport, response to abscisic acid stimulus, regulation of stomatal movement; LOCATED IN: nucleus, plasma membrane, vacuole, membrane; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, plasma-membrane proton-efflux (InterPro:IPR006534), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: H(+)-ATPase 2 (TAIR:AT4G30190.1); Has 37421 Blast hits to 33000 proteins in 3185 species: Archae - 713; Bacteria - 23967; Metazoa - 3870; Fungi - 2594; Plants - 1874; Viruses - 3; Other Eukaryotes - 4400 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8221514..8227622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335616.1 → NP_001324052.1  H[+]-ATPase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYX4, C0Z2R2
      Conserved Domains (1) summary
      TIGR01647
      Location:1 → 740
      ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase

    2. NM_127453.4 → NP_179486.1  H[+]-ATPase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179486.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64626, P20649
      UniProtKB/TrEMBL
      A0A178VSN5, A0A5S9WZI0, C0Z2R2
      Conserved Domains (1) summary
      TIGR01647
      Location:32 → 804
      ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase

    3. NM_001335617.1 → NP_001324051.1  H[+]-ATPase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYX4, C0Z2R2
      Conserved Domains (1) summary
      TIGR01647
      Location:1 → 740
      ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20649.3

    Gene LinkOut

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