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    CYP707A2 cytochrome P450, family 707, subfamily A, polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817457, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP707A2
    Official Full Name
    cytochrome P450, family 707, subfamily A, polypeptide 2
    Primary source
    TAIR:AT2G29090
    Locus tag
    AT2G29090
    See related
    Araport:AT2G29090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; family 707; polypeptide 2; polypeptide 2''; subfamily A; T9I4.17; T9I4_17
    Summary
    Encodes a protein with ABA 8'-hydroxylase activity, involved in ABA catabolism. Member of the CYP707A gene family. This gene predominantly accumulates in dry seeds and is up-regulated immediately following imbibition. CYP707A2 appears to play a major role in the rapid decrease in ABA levels during early seed imbibition.
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    Genomic context

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    See CYP707A2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (12494826..12499723, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ubiquitin fusion degradation UFD1 family protein Neighboring gene FTSH protease 3 Neighboring gene ncRNA Neighboring gene glutamate receptor 2.9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of the abscisic acid catabolic gene CYP707A2 in the glucose-induced delay in seed germination and post-germination growth of Arabidopsis. Zhu G, et al. Physiol Plant, 2011 Dec. PMID 21883251
    2. The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy. Matakiadis T, et al. Plant Physiol, 2009 Feb. PMID 19074630, Free PMC Article
    3. The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism. Kushiro T, et al. EMBO J, 2004 Apr 7. PMID 15044947, Free PMC Article
    4. NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis. Yan D, et al. Nat Commun, 2016 Oct 12. PMID 27731416, Free PMC Article
    5. CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Okamoto M, et al. Plant Physiol, 2006 May. PMID 16543410, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2.
      Title: NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis.
    2. Glucose-induced delay in seed germination and seedling development is directly related to the suppression of ABA catabolism through the repression of the CYP707A2 expression.
      Title: Involvement of the abscisic acid catabolic gene CYP707A2 in the glucose-induced delay in seed germination and post-germination growth of Arabidopsis.
    3. central role of the CYP707A2 gene in the nitrate-mediated control of Abscisic acid levels during seed development and germination of arabidopsis thaliana.
      Title: The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy.
    4. CYP707A2 transcript levels increase from late-maturation to mature dry seed and plays a distinct role in seed development and postgermination growth.
      Title: CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202700.1
    NM_001336198.1
    NM_001336199.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    NOT enables (+)-abscisic acid 8'-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (+)-abscisic acid 8'-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within release of seed from dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 707, subfamily A, polypeptide 2
    NP_001189629.1
    • ''cytochrome P450, family 707, subfamily A, polypeptide 2'' (CYP707A2); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1).
    NP_180473.1
    • ''cytochrome P450, family 707, subfamily A, polypeptide 2'' (CYP707A2); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 36442 Blast hits to 36296 proteins in 1886 species: Archae - 82; Bacteria - 8337; Metazoa - 11529; Fungi - 6203; Plants - 8178; Viruses - 6; Other Eukaryotes - 2107 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12494826..12499723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128466.4 → NP_180473.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81077
      UniProtKB/TrEMBL
      A0A5S9X2D0, A0A654EY99
      Conserved Domains (1) summary
      cl12078
      Location:45 → 477
      p450; Cytochrome P450

    2. NM_001202700.1 → NP_001189629.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81077
      UniProtKB/TrEMBL
      A0A5S9X2D0, A0A654EY99
      Conserved Domains (1) summary
      cl12078
      Location:45 → 477
      p450; Cytochrome P450

    3. NM_001336198.1 → NP_001324571.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0J6, A0A5S9X2D0, A0A654EY99

    4. NM_001336199.1 → NP_001324570.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0N0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81077.1

    Gene LinkOut

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