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    PH1 pleckstrin homologue 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817520, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PH1
    Official Full Name
    pleckstrin homologue 1
    Primary source
    TAIR:AT2G29700
    Locus tag
    AT2G29700
    See related
    Araport:AT2G29700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPH1; pleckstrin homologue 1; T27A16.20; T27A16_20
    Summary
    Encodes a protein containing one PH (pleckstrin homology) domain with a short N-terminal extension
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    Genomic context

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    See PH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (12697226..12698291)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cell division control 6 Neighboring gene anthranilate synthase 2 Neighboring gene UDP-Glycosyltransferase superfamily protein Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis. Agorio A, et al. Proc Natl Acad Sci U S A, 2017 Apr 18. PMID 28373552, Free PMC Article
    2. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
    3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that loss of AtPH1 function leads to the mislocalization of the metal uptake transporter NRAMP1 to the vacuole, providing a rationale for the reversion of nramp3nramp4 phenotypes
      Title: Phosphatidylinositol 3-phosphate-binding protein AtPH1 controls the localization of the metal transporter NRAMP1 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128524.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome HDA PubMed 

    General protein information

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    Preferred Names
    pleckstrin homologue 1
    NP_565687.1
    • pleckstrin homologue 1 (PH1); CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Pleckstrin homology (PH) domain superfamily protein (TAIR:AT5G05710.1); Has 2358 Blast hits to 2352 proteins in 131 species: Archae - 0; Bacteria - 0; Metazoa - 1854; Fungi - 32; Plants - 108; Viruses - 3; Other Eukaryotes - 361 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12697226..12698291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128524.4 → NP_565687.1  pleckstrin homologue 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82386, Q9ST43
      UniProtKB/TrEMBL
      A0A178W3K4, A0A5S9X2D6
      Conserved Domains (1) summary
      cd13276
      Location:29 → 136
      PH_AtPH1; Arabidopsis thaliana Pleckstrin homolog (PH) 1 (AtPH1) PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ST43.2

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