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    MOT1 molybdate transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817109, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MOT1
    Official Full Name
    molybdate transporter 1
    Primary source
    TAIR:AT2G25680
    Locus tag
    AT2G25680
    See related
    Araport:AT2G25680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3N11.13; F3N11_13; molybdate transporter 1
    Summary
    Encodes a high-affinity molybdate transporter. Mutant has reduced concentrations of molybdate in roots and shoots, and reduced shoot and root length when growing on Mo-limited medium.
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    Genomic context

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    See MOT1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (10933005..10934604, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator Neighboring gene embryo defective 2410 Neighboring gene uncharacterized protein Neighboring gene SCR-like 17 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molybdenum metabolism in plants. Tejada-Jiménez M, et al. Metallomics, 2013 Sep. PMID 23800757
    2. Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient. Poormohammad Kiani S, et al. PLoS Genet, 2012. PMID 22807689, Free PMC Article
    3. Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana. Ide Y, et al. J Exp Bot, 2011 Feb. PMID 21131548
    4. Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1). Baxter I, et al. PLoS Genet, 2008 Feb 29. PMID 18454190, Free PMC Article
    5. An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil. Tomatsu H, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18003916, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two of the three polymorphisms underlying the genetic variance-heterogeneity are promoter variants for Molybdate transporter 1 (MOT1), and the third a variant located ~25 kb downstream of this gene.
      Title: The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance.
    2. Studies indicate that AtMOT1;1 showed specific and high affinity molybdate transport process.
      Title: Molybdenum metabolism in plants.
    3. we have identified a new functional variant at MOT1 that contributes to explain most of the species' diversity in Mo homeostasis, and associated phenotypes that provide likely explanations for its non neutral evolution and its correlation to native soil.
      Title: Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.
    4. MOT1 has a role in maintaining primary metabolism of nitrogen, carbon, and sulfur under molybdenum deficiency.
      Title: Effects of molybdenum deficiency and defects in molybdate transporter MOT1 on transcript accumulation and nitrogen/sulphur metabolism in Arabidopsis thaliana.
    5. A deletion in the MOT1 promoter is strongly associated with low shoot Mo, occurring in seven of the accessions with the lowest shoot content of Mo.
      Title: Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1).
    6. Molybdate transporter, MOT1, is specific for molybdate and that the high affinity of MOT1 allows plants to obtain scarce Mo from soil. [MOT1]
      Title: An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    NM_128127.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molybdate ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within molybdate ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within molybdate ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    molybdate transporter 1
    NP_180139.1
    • molybdate transporter 1 (MOT1); FUNCTIONS IN: molybdate ion transmembrane transporter activity, sulfate transmembrane transporter activity; INVOLVED IN: molybdate ion transport; LOCATED IN: mitochondrion, vacuole; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; BEST Arabidopsis thaliana protein match is: sulfate transmembrane transporters (TAIR:AT1G80310.1); Has 761 Blast hits to 750 proteins in 291 species: Archae - 26; Bacteria - 503; Metazoa - 6; Fungi - 58; Plants - 70; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10933005..10934604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128127.4 → NP_180139.1  molybdate transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SL95
      UniProtKB/TrEMBL
      A0A654EXK6
      Conserved Domains (1) summary
      pfam16983
      Location:36 → 147
      MFS_MOT1; Molybdate transporter of MFS superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SL95.1

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