PIN7 Auxin efflux carrier family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PIN7
Official Full Name: Auxin efflux carrier family protein
Primary source: TAIR:AT1G23080
Locus tag: AT1G23080
See related: Araport:AT1G23080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS PIN-FORMED 7; ATPIN7; PIN-FORMED 7; T26J12.14; T26J12_14
Summary: Encodes a novel component of auxin efflux that is located apically in the basal cell and is involved during embryogenesis in setting up the apical-basal axis in the embryo. It is also involved in pattern specification during root development. In roots, it is expressed at lateral and basal membranes of provascular cells in the meristem and elongation zone, whereas in the columella cells it coincides with the PIN3 domain. Plasma membrane-localized PIN proteins mediate a saturable efflux of auxin. PINs mediate auxin efflux from mammalian and yeast cells without needing additional plant-specific factors. The action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. PINs are directly involved of in catalyzing cellular auxin efflux.
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Genomic context

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See PIN7 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 6

Sequence:: Chromosome: 1; NC_003070.9 (8180189..8183650, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutually opposing activity of PIN7 splicing isoforms is required for auxin-mediated tropic responses in Arabidopsis thaliana.
Title: Mutually opposing activity of PIN7 splicing isoforms is required for auxin-mediated tropic responses in Arabidopsis thaliana.
Jasmonic acid mediates xylem development by controlling polar auxin transport with PIN7 critically involved in this process.
Title: Jasmonic Acid Modulates Xylem Development by Controlling Expression of PIN-FORMED 7.
PIN7 role in shoot branching.
Title: Cytokinin Targets Auxin Transport to Promote Shoot Branching.
The exit from the plateau phase correlates with an increase in auxin signalling at the tip of the young lateral roots. These data suggests that the developmental increase in auxin triggers the preferential derepression of PIN7 in gravity-sensing columella cells. The subsequent polarization of PIN7 heralds the bending towards gravity and, hence, the exit from the plateau phase.
Title: PIN7 Auxin Carrier Has a Preferential Role in Terminating Radial Root Expansion in Arabidopsis thaliana.
activating a steroid-inducible variant of the auxin response factor (ARF) MONOPTEROS (MP) is sufficient to restore patterning and PIN gene expression.
Title: The auxin response factor MONOPTEROS controls meristem function and organogenesis in both the shoot and root through the direct regulation of PIN genes.
ABA treatment reduced the expression levels of the PIN-FORMEDs (PIN) auxin efflux carriers, PIN1, PIN3, PIN4, and PIN7, to a greater extent in the root meristems of arf2-101 mutant than in the wild type. ARF2 positively mediates the transcripts of transcription factor PLETHORA 1 (PLT1) gene but negatively mediates PLT2 at protein level in root meristems.
Title: ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.
Title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism.
Functional interplay between protein kinase CK2 and salicylic acid sustains PIN7 transcriptional expression.
Title: Functional interplay between protein kinase CK2 and salicylic acid sustains PIN transcriptional expression and root development.
Data show that phototropic hypocotyl bending is strongly dependent on the activity of D6PKs and the PIN-FORMED (PIN) auxin efflux facilitators PIN3, PIN4, and PIN7.
Title: D6PK AGCVIII kinases are required for auxin transport and phototropic hypocotyl bending in Arabidopsis.
APSR1 is required for the coordination of cell processes necessary for correct root growth in response to phosphate starvation conceivably by direct or indirect modulation of PIN7.
Title: APSR1, a novel gene required for meristem maintenance, is negatively regulated by low phosphate availability.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001332585.1

Supported by ESTs:

NM_102156.1

Supported by ESTs:

NM_179369.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to alkaline pH	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within longitudinal axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within root development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: Auxin efflux carrier family protein

NP_001319066.1

PIN-FORMED 7 (PIN7); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity, auxin efflux transmembrane transporter activity; INVOLVED IN: response to cyclopentenone, root development, pattern specification process, auxin polar transport, longitudinal axis specification; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 1749 Blast hits to 1582 proteins in 451 species: Archae - 37; Bacteria - 920; Metazoa - 12; Fungi - 2; Plants - 486; Viruses - 0; Other Eukaryotes - 292 (source: NCBI BLink).

NP_564189.1

PIN-FORMED 7 (PIN7); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity, auxin efflux transmembrane transporter activity; INVOLVED IN: response to cyclopentenone, root development, pattern specification process, auxin polar transport, longitudinal axis specification; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 700 Blast hits to 605 proteins in 126 species: Archae - 0; Bacteria - 174; Metazoa - 8; Fungi - 2; Plants - 457; Viruses - 0; Other Eukaryotes - 59 (source: NCBI BLink).

NP_849700.1

PIN-FORMED 7 (PIN7); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity, auxin efflux transmembrane transporter activity; INVOLVED IN: response to cyclopentenone, root development, pattern specification process, auxin polar transport, longitudinal axis specification; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 1748 Blast hits to 1583 proteins in 451 species: Archae - 37; Bacteria - 919; Metazoa - 14; Fungi - 2; Plants - 486; Viruses - 0; Other Eukaryotes - 290 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

8180189..8183650 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001084115.2 → NP_001077584.1 Auxin efflux carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001077584.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIH0, A0A654ECC1, A8MQX0

Conserved Domains (1) summary

pfam03547
Location:9 → 190

Mem_trans; Membrane transport protein
NM_179369.2 → NP_849700.1 Auxin efflux carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849700.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49308, Q940Y5, Q9SQH5

UniProtKB/TrEMBL

A0A178WIH0, A0A5S9VNI1, A0A654ECC1

Conserved Domains (1) summary

pfam03547
Location:9 → 190

Mem_trans; Membrane transport protein
NM_001332585.1 → NP_001319066.1 Auxin efflux carrier family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIH0, A0A654ECC1, A8MQX0

Conserved Domains (1) summary

pfam03547
Location:9 → 190

Mem_trans; Membrane transport protein
NM_102156.1 → NP_564189.1 Auxin efflux carrier family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_564189.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WIH0, A0A654ECC1

Conserved Domains (2) summary

pfam03547
Location:9 → 190

Mem_trans; Membrane transport protein

cl22894
Location:451 → 516

Mem_trans; Membrane transport protein