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    FAS1 chromatin assembly factor-1 (FASCIATA1) (FAS1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842858, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAS1
    Official Full Name
    chromatin assembly factor-1 (FASCIATA1) (FAS1)
    Primary source
    TAIR:AT1G65470
    Locus tag
    AT1G65470
    See related
    Araport:AT1G65470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FASCIATA 1; FUGU 2; FUGU2; NFB2; NUCLEOSOME/CHROMATIN ASSEMBLY FACTOR GROUP B
    Summary
    Chromatin Assembly Factor-1 (CAF-1) p150 subunit. Mutants have reduced heterochromatin content. In Arabidopsis, the three CAF-1 subunits are encoded by FAS1, FAS2 and, most likely, MSI1, respectively. Mutations in FAS1 or FAS2 lead to increased frequency of homologous recombination and T-DNA integration in Arabidopsis.
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    Genomic context

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    See FAS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (24319396..24324091, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene global transcription factor group B1 Neighboring gene HXXXD-type acyl-transferase family protein Neighboring gene PEBP (phosphatidylethanolamine-binding protein) family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance. Mozgova I, et al. New Phytol, 2018 Nov. PMID 29573427
    2. The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants. Kirik A, et al. Plant Cell, 2006 Oct. PMID 16980538, Free PMC Article
    3. Control of trichome branching by chromatin assembly factor-1. Exner V, et al. BMC Plant Biol, 2008 May 13. PMID 18477400, Free PMC Article
    4. E2F regulates FASCIATA1, a chromatin assembly gene whose loss switches on the endocycle and activates gene expression by changing the epigenetic status. Ramirez-Parra E, et al. Plant Physiol, 2007 May. PMID 17351056, Free PMC Article
    5. Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis. Tulin F. Plant Physiol, 2021 Aug 3. PMID 34618115, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
      Title: Buying time: FASCIATA1 deficiency rescues wee1 plants from replication stress by delaying mitosis.
    2. G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
      Title: G2/M-checkpoint activation in fasciata1 rescues an aberrant S-phase checkpoint but causes genome instability.
    3. Disruption of NAP1 genes in Arabidopsis thaliana suppresses the fas1 mutant phenotype, enhances genome stability and changes chromatin compaction.
      Title: Disruption of NAP1 genes in Arabidopsis thaliana suppresses the fas1 mutant phenotype, enhances genome stability and changes chromatin compaction.
    4. epigenetic rather than genetic mechanisms underlie the progressive developmental phenotype aggravation in the Arabidopsis CAF-1 mutants.
      Title: Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance.
    5. Loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions.
      Title: The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.
    6. ATM-dependent DNA damage response acts as an upstream trigger in fas1 to delay the cell cycle and promote entry into the endocycle, resulting in compensated cell expansion.
      Title: The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development.
    7. Telomere shortening is more rapid in fas tert double mutants than in fas1, fas2 or tert single mutant plants.
      Title: A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana.
    8. CYP71 physically interacts with FAS1 and LHP1 to modulate their distribution on chromatin.
      Title: The cyclophilin AtCYP71 interacts with CAF-1 and LHP1 and functions in multiple chromatin remodeling processes.
    9. Mutations in the FAS1 and FAS2 cause a progressive reduction of telomeric and 45S rDNA repeats.
      Title: Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana.
    10. CAF-1 is required for cell differentiation and regulates trichome development together with STICHEL in an endoreduplication-independent pathway.[CAF-1]
      Title: Control of trichome branching by chromatin assembly factor-1.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198391.1
    NM_105221.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    chromatin assembly factor-1 (FASCIATA1) (FAS1)
    NP_001185320.1
    • FASCIATA 1 (FAS1); FUNCTIONS IN: histone binding; INVOLVED IN: in 11 processes; LOCATED IN: chromatin assembly complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Chromatin assembly factor 1 subunit A (InterPro:IPR022043).
    NP_176725.1
    • FASCIATA 1 (FAS1); CONTAINS InterPro DOMAIN/s: Chromatin assembly factor 1 subunit A (InterPro:IPR022043); Has 59418 Blast hits to 36461 proteins in 1994 species: Archae - 284; Bacteria - 7518; Metazoa - 24571; Fungi - 4236; Plants - 1982; Viruses - 348; Other Eukaryotes - 20479 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24319396..24324091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105221.3 → NP_176725.1  chromatin assembly factor-1 (FASCIATA1) (FAS1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04466, O80817, Q9SXY0
      UniProtKB/TrEMBL
      A0A178WE31, A0A5S9WS76
      Conserved Domains (3) summary
      PRK09510
      Location:230 → 336
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      pfam12253
      Location:481 → 549
      CAF1A; Chromatin assembly factor 1 subunit A
      NF033930
      Location:175 → 396
      pneumo_PspA; pneumococcal surface protein A

    2. NM_001198391.1 → NP_001185320.1  chromatin assembly factor-1 (FASCIATA1) (FAS1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WE31, F4IBG1
      Conserved Domains (2) summary
      pfam11262
      Location:266 → 356
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam12253
      Location:473 → 541
      CAF1A; Chromatin assembly factor 1 subunit A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SXY0.1

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