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    HCAR coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839472, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCAR
    Official Full Name
    coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family
    Primary source
    TAIR:AT1G04620
    Locus tag
    AT1G04620
    See related
    Araport:AT1G04620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    7-hydroxymethyl chlorophyll a (HMChl) reductase; T1G11.13; T1G11_13
    Summary
    Encodes a 7-hydroxymethyl chlorophyll a reductase, an enzyme of the chlorophyll cycle that converts 7-hydroxymethyl chlorophyll a to chlorophyll a.
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    Genomic context

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    See HCAR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (1282163..1286619, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene myosin XI A Neighboring gene YUCCA 3 Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein Neighboring gene GRIM-19 protein Neighboring gene ribonuclease P family protein / Rpp14 family protein Neighboring gene lipoyltransferase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpressing 7-Hydroxymethyl Chlorophyll a Reductase Alleviates Non-Programmed Cell Death during Dark-Induced Senescence in Intact Arabidopsis Plants. Hu X, et al. Biomolecules, 2021 Aug 3. PMID 34439809, Free PMC Article
    2. HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll b Degradation in Chlorophyll-b-Overproducing Plants. Zhao X, et al. Biomolecules, 2020 Dec 5. PMID 33291365, Free PMC Article
    3. Rice 7-Hydroxymethyl Chlorophyll a Reductase Is Involved in the Promotion of Chlorophyll Degradation and Modulates Cell Death Signaling. Piao W, et al. Mol Cells, 2017 Oct. PMID 29047257, Free PMC Article
    4. Crystal Structure and Catalytic Mechanism of 7-Hydroxymethyl Chlorophyll a Reductase. Wang X, et al. J Biol Chem, 2016 Jun 17. PMID 27072131, Free PMC Article
    5. Identification of the 7-hydroxymethyl chlorophyll a reductase of the chlorophyll cycle in Arabidopsis. Meguro M, et al. Plant Cell, 2011 Sep. PMID 21934147, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpressing 7-Hydroxymethyl Chlorophyll a Reductase Alleviates Non-Programmed Cell Death during Dark-Induced Senescence in Intact Arabidopsis Plants.
      Title: Overexpressing 7-Hydroxymethyl Chlorophyll a Reductase Alleviates Non-Programmed Cell Death during Dark-Induced Senescence in Intact Arabidopsis Plants.
    2. HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll b Degradation in Chlorophyll-b-Overproducing Plants.
      Title: HCAR Is a Limitation Factor for Chlorophyll Cycle and Chlorophyll b Degradation in Chlorophyll-b-Overproducing Plants.
    3. addition to functioning in the conversion of 7-HMC a to Chl a in senescent leaves, HCAR may play a critical role in protecting plants from high light-induced damage by preventing the accumulation of 7-HMC a and Pheo a in developing and mature leaves at the vegetative stage
      Title: Rice 7-Hydroxymethyl Chlorophyll a Reductase Is Involved in the Promotion of Chlorophyll Degradation and Modulates Cell Death Signaling.
    4. report the crystal structure of Arabidopsis HCAR at 2.7-A resolution and reveal that two [4Fe-4S]clusters and one FAD within a very short distance form a consecutive electron pathway to the substrate pocket. In vitro kinetic analysis confirms the ferredoxin-dependent electron transport chain, thus supporting a proton-activated electron transfer mechanism.
      Title: Crystal Structure and Catalytic Mechanism of 7-Hydroxymethyl Chlorophyll a Reductase.
    5. in Arabidopsis, 7-hydroxymethyl chlorophyll a reductase overexpressing plants exhibited accelerated leaf yellowing and, conversely, hcar mutants stayed green during dark-induced senescence.
      Title: 7-Hydroxymethyl chlorophyll a reductase functions in metabolic channeling of chlorophyll breakdown intermediates during leaf senescence.
    6. 7-hydroxymethyl chlorophyll a reductase contains flavin adenine dinucleotide and an iron-sulfur center. It converts 7-hydroxymethyl chlorophyll a to chlorophyll a using ferredoxin.
      Title: Identification of the 7-hydroxymethyl chlorophyll a reductase of the chlorophyll cycle in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100341.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 7-hydroxymethyl chlorophyll a reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chlorophyll cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within chlorophyll metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family
    NP_171956.2
    • coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family; FUNCTIONS IN: coenzyme F420 hydrogenase activity; INVOLVED IN: biological_process unknown; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Coenzyme F420 hydrogenase/dehydrogenase beta subunit, C-terminal (InterPro:IPR007525), Coenzyme F420 hydrogenase/dehydrogenase beta subunit, N-terminal (InterPro:IPR007516); Has 499 Blast hits to 498 proteins in 165 species: Archae - 202; Bacteria - 188; Metazoa - 0; Fungi - 0; Plants - 41; Viruses - 0; Other Eukaryotes - 68 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1282163..1286619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100341.4 → NP_171956.2  coenzyme F420 hydrogenase family / dehydrogenase, beta subunit family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171956.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23023, Q8GS60
      UniProtKB/TrEMBL
      A0A178W7H4
      Conserved Domains (1) summary
      cl27156
      Location:56 → 358
      FrhB_FdhB_C; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GS60.1

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