CNGC12 cyclic nucleotide-gated channel 12 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CNGC12
Official Full Name: cyclic nucleotide-gated channel 12
Primary source: TAIR:AT2G46450
Locus tag: AT2G46450
See related: Araport:AT2G46450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCNGC12; cyclic nucleotide-gated channel 12; F11C10.14
Summary: Member of Cyclic nucleotide gated channel family.Positive regulator of resistance against avirulent fungal pathogen.Suppresses the phenotype conferred by cpr22 in a dosage-dependent manner.
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Genomic context

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See CNGC12 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 9

Sequence:: Chromosome: 2; NC_003071.7 (19065536..19069569)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of CNGC12 with a nonfunctional N-terminal CaMBD constitutively induced programmed cell death, providing in planta evidence of allosteric CNGC regulation by CaM. Furthermore, study determined that CaM binding to the IQ motif was required for channel function, indicating that CaM can both positively and negatively regulate CNGC12.
Title: Multiple Calmodulin-Binding Sites Positively and Negatively Regulate Arabidopsis CYCLIC NUCLEOTIDE-GATED CHANNEL12.
residues important for intersubunit interactions of CNGC12 and CNGC11
Title: A suppressor screen of the chimeric AtCNGC11/12 reveals residues important for intersubunit interactions of cyclic nucleotide-gated ion channels.
AtCNGC11 and 12 mediates a Ca2+ signal that is involved not only in plant immunity, but also in developmental processes such as gravitropic bending and senescence.
Title: High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis.
AtCNGC11 and 12 gene expression was induced during dark-induced senescence and AtCNGC11 and 12 knockout mutants displayed enhanced chlorophyll loss, which was even more pronounced in the double mutant, also indicating synergistic roles in senescence.
Title: The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner.
AlphaC-helix in the cyclic nucleotide binding domain is functionally important for CNGC11 and CNGC12.
Title: Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis.
A 3-kb deletion fuses two cyclic nucleotide-gated ion channel (ATCNGC)-encoding genes, ATCNGC11 and ATCNGC12, to generate a novel chimeric gene, ATCNGC11/12.
Title: The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001202829.2

Supported by ESTs:

NM_001202830.1

Supported by ESTs:

NM_001337192.1

Supported by ESTs:

NM_180123.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to fungus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclic nucleotide-gated channel 12

NP_001189758.1

cyclic nucleotide-gated channel 12 (CNGC12); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channels (TAIR:AT2G46440.1).

NP_001189759.1

cyclic nucleotide-gated channel 12 (CNGC12); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cyclic nucleotide-binding-like (InterPro:IPR018490), Ion transport (InterPro:IPR005821), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channels (TAIR:AT2G46440.1).

NP_850454.5

cyclic nucleotide-gated channel 12 (CNGC12); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channels (TAIR:AT2G46440.1); Has 2667 Blast hits to 2622 proteins in 213 species: Archae - 0; Bacteria - 16; Metazoa - 1408; Fungi - 0; Plants - 925; Viruses - 0; Other Eukaryotes - 318 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19065536..19069569

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180123.6 → NP_850454.5 cyclic nucleotide-gated channel 12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850454.5

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GWD2, Q9SKD5

UniProtKB/TrEMBL

A0A5S9X7J1, B3FXQ3

Conserved Domains (2) summary

cd00038
Location:435 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:302 → 362

Ion_trans; Ion transport protein
NM_001337192.1 → NP_001324486.1 cyclic nucleotide-gated channel 12 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GWD2, Q9SKD5

UniProtKB/TrEMBL

A0A5S9X7J1, B3FXQ3

Conserved Domains (2) summary

cd00038
Location:435 → 560

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:302 → 362

Ion_trans; Ion transport protein
NM_001202829.2 → NP_001189758.1 cyclic nucleotide-gated channel 12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189758.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654F2G8, F4II93

Conserved Domains (1) summary

cd00038
Location:399 → 524

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
NM_001202830.1 → NP_001189759.1 cyclic nucleotide-gated channel 12 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189759.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654F2G8, F4II92

Conserved Domains (1) summary

cd00038
Location:412 → 537

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...